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Genes of Human Catecholamine-Synthesizing Enzymes

  • Toshiharu Nagatsu
  • Norio Kaneda
  • Kazuto Kobayashi
  • Hiroshi Ichinose
  • Toshikuni Sasaoka
  • Akira Ishii
  • Kazutoshi Kiuchi
  • Keisuke Fujita
  • Koichi Titani
  • Yoshikazu Kurosawa
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Catecholamines (CA; i.e., dopamine, noradrenaline, and adrenaline) are neurotransmitters in dopamine, noradrenaline, adrenaline neurons in the brain and play important roles in Alzheimer’s and Parkinson’s diseases. CA are synthesized from tyrosine in the following pathway: tyrosine → 3, 4-dihydroxyphenylalanine (DOPA) →dopamine →noradrenaline → adrenaline. Thus, four enzymes catalyze the biosynthesis of adrenaline: (1)tyrosine hydroxylase (TH), (2)aromatic Lamino acid decarboxylase (AADC, or DOPA decarboxylase, DDC), (3)dopamine β-hydroxylase (DBH), and (4)phenylethanolamine N-methyltransferase. We have cloned and characterized cDNA’s of TH, AADC, DBH, and PNMT genes and genomic DNA’s of TH, DBH, and PNMT. We determined the nucleotide and deduced amino acid sequences of human CA-synthesizing enzymes.

Keywords

Tyrosine Hydroxylase Deduce Amino Acid Sequence Dopa Decarboxylase Alternative Polyadenylation Human Dopamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Toshiharu Nagatsu
    • 1
  • Norio Kaneda
    • 1
  • Kazuto Kobayashi
    • 1
  • Hiroshi Ichinose
    • 1
  • Toshikuni Sasaoka
    • 1
  • Akira Ishii
    • 1
  • Kazutoshi Kiuchi
    • 2
  • Keisuke Fujita
    • 3
  • Koichi Titani
    • 3
  • Yoshikazu Kurosawa
    • 3
  1. 1.Department of BiochemistryNgoya University School of MedicineNagoya 466Japan
  2. 2.Radioisotope Center Medical DivisionNgoya University School of MedicineNagoya 466Japan
  3. 3.Institute for Comprehensive Medical ScienceFujita Health UniversityToyoake, AichiJapan

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