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Behavioral and Neurochemical Evaluation of Stroke-Prone Spontaneously Hypertensive Rats for Vascular Dementia-Animal Model

  • Hiroko Togashi
  • Machiko Matsumoto
  • Mitsuhiro Yoshioka
  • Masaru Minami
  • Hideya Saito
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The stroke-prone spontaneously hypertensive rat (SHRSP) is known to be an unique model of stroke because the lethal time course of SHRSP coincides well with that of patients with cerebrovascular lesions (Okamoto et al., 1974). The aim of the present study was to clarify the proposed possibility that. SHRSP may be a vascular dementia-animal model. First, a study was carried out to evaluate stroke-related behavioral changes and learning ability using passive avoidance response. An attempt was also made to investigate the pathophysiology of SHRSP as an animal model for cerebrovascular lesions by determining neurotransmitter levels in cerebrospinal fluid (CSF).

Keywords

Passive Avoidance Retention Test Pheny Lacetic Acid Acquisition Trial Passive Avoidance Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Davis, K.L., Hsieh, JY-K, Levy, M.I., Horvath, T.B. Davis, B.M. and Mohs, R.C., 1982, Cerebrospinal acetylcholine, choline and senile dementia of the Alzheimer type, Psychopharmacol. Bull., 18: 193.PubMedGoogle Scholar
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hiroko Togashi
    • 1
  • Machiko Matsumoto
    • 1
  • Mitsuhiro Yoshioka
    • 1
  • Masaru Minami
    • 2
  • Hideya Saito
    • 1
  1. 1.1st Dept. of Pharmacol.Hokkaido Univ. School of Med.Sapporo 060Japan
  2. 2.Dept. of Pharmacol., Fac. of Pharm. Sci.Higashi-Nippon-Gakuen Univ.Ishikari-Tobetsu Hokkaido 061-02Japan

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