Behavioral and Neurochemical Evaluation of Stroke-Prone Spontaneously Hypertensive Rats for Vascular Dementia-Animal Model
The stroke-prone spontaneously hypertensive rat (SHRSP) is known to be an unique model of stroke because the lethal time course of SHRSP coincides well with that of patients with cerebrovascular lesions (Okamoto et al., 1974). The aim of the present study was to clarify the proposed possibility that. SHRSP may be a vascular dementia-animal model. First, a study was carried out to evaluate stroke-related behavioral changes and learning ability using passive avoidance response. An attempt was also made to investigate the pathophysiology of SHRSP as an animal model for cerebrovascular lesions by determining neurotransmitter levels in cerebrospinal fluid (CSF).
KeywordsPassive Avoidance Retention Test Pheny Lacetic Acid Acquisition Trial Passive Avoidance Response
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