Pharmacological Profile of Brain Glucose Utilization Obtained by Monitoring of Lactate Release in Vivo under the Free Moving Condition

  • Masatoshi Takita
  • Masahiko Mikuni
  • Kiyohisa Takahashi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

In recent years, knowledge has been accumulated about dynamic roles of the brain in accordance with progress in science technology. For example, glucose uptake ratio, O2 utilization, and blood flow rate in the CNS were obtained by autoradiography, positron emission tomography, and magnetic resonance imaging. From data obtained by these means and others, it was assumed that glucose utilization in the CNS was important not only as the basis of cell physiology but also for psychophysiological functions. It is also important to know the relationship between behavior and neuronal activities in several brain regions, in order to conduct basic research on Alzheimer’s diseases, Parkinson’s disease, and other neuro-psychological diseases. And it would be essential for the research to investigate the sites of action of therapeutic drugs for those diseases on the background of the brain glycolytic pathway. But it was hard to observe both the brain glucose utilization and its behavior (cf. 2-deoxy-D-glucose method).

Keywords

Dopamine Lactate Serotonin NMDA NADH 

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References

  1. 1.
    E. M. C. Schasfoort, L. A. De Gruin, and J. Korf, Mild stress stimulates rat hippocampal glucose utilization transiently via NMDA receptors, as assessed by lactography, Brain Res. 475: 58–63 (1988).PubMedCrossRefGoogle Scholar
  2. 2.
    G. W. Small, D. E. Kuhl, W. H. Riege, D. G. Fujikawa, J. W. Ashford, E. J. Metter, and J. C. Mazziotta, Cerebral glucose metabolic patterns in Alzheimer’s disease, Arch. Gen. Psychiatry 46: 527–532 (1989).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Masatoshi Takita
    • 1
  • Masahiko Mikuni
    • 1
  • Kiyohisa Takahashi
    • 1
  1. 1.Division of Mental Disorder Research, National Institute of NeuroscienceNCNPTokyoJapan

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