In Vitro Experimental Approach for Determination of the Central Cholinergic Neuronal Activity
Dysfunction of the central cholinergic neurons is observed in patients with Alzheimer’s disease and other motor disorders. Drugs exerting effects on central cholinergic activities have been used for therapy in these diseases. Therefore, a simple in vitro experimental system for measurement of cholinergic neuronal activity is required for pathological and pharmacological studies, and for the screening of drugs potentially effective for the above diseases.
KeywordsFrontal Cortex Cholinergic Neuron Basal Forebrain Caudate Putamen Central Cholinergic Neuron
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