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In Vitro Experimental Approach for Determination of the Central Cholinergic Neuronal Activity

  • Takeshi Suzuki
  • Yuko Kashima
  • Kazuko Fujimoto
  • Hisayo Oohata
  • Koichiro Kawashima
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Dysfunction of the central cholinergic neurons is observed in patients with Alzheimer’s disease and other motor disorders. Drugs exerting effects on central cholinergic activities have been used for therapy in these diseases. Therefore, a simple in vitro experimental system for measurement of cholinergic neuronal activity is required for pathological and pharmacological studies, and for the screening of drugs potentially effective for the above diseases.

Keywords

Frontal Cortex Cholinergic Neuron Basal Forebrain Caudate Putamen Central Cholinergic Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Takeshi Suzuki
    • 1
  • Yuko Kashima
    • 1
  • Kazuko Fujimoto
    • 1
  • Hisayo Oohata
    • 1
  • Koichiro Kawashima
    • 1
  1. 1.Department of PharmacologyKyoritsu College of PharmacyMinato-ku, Tokyo 105Japan

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