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Nigrostriatal Loop Disruption in Parkinson’s Disease and Striatonigral Degeneration

  • Sadayuki Matsumoto
  • Satoshi Goto
  • Asao Hirano
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Parkinson’s disease (PD) is known to involve degeneration of nigrostriatal dopaminergic neurons, resulting in a dopamine deficiency in the striatum.1 On the other hand, parkinsonism has been described as a clinical manifestation of other extrapyramidal disorders, such as striatonigral degeneration (SND)2 and progressive supranuclear palsy.3 SND was first described as a distinct clinicopathological entity by Adams et al.,2 and symptoms of pure SND are those of PD; while in the SND patients rigidity and slowness of movement of extremities are prominent.2 In addition, it is noteworthy that SND has been suggested to be a true supranigral form of parkinsonism, in which the striatal lesion is supposed to procede the nigral involvement.4

Keywords

Tyrosine Hydroxylase Substantia Nigra Dopaminergic Neuron Progressive Supranuclear Palsy Lateral Portion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Sadayuki Matsumoto
    • 1
  • Satoshi Goto
    • 1
  • Asao Hirano
    • 1
  1. 1.Bluestone Laboratory of the Division of Neuropathology Department of Pathology, Montefiore Medical CenterAlbert Einstein College of MedicineBronxUSA

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