Immune System Reaction to Model Lesions of Rat Brain

  • Haruhiko Akiyama
  • Shigeru Itagaki
  • Patrick L. McGeer
  • Edith G. McGeer
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Traditional ideas about how the immune system responds to injury and infection of neural tissue are now being revised, particularly with respect to intervention by T-lymphocytes. They require major histocompatibility complex (MHC) antigens for cellular recognition. Recent investigations have revealed the vigorous expression of HLA-DR, a MHC class II antigen by reactive microglia in Alzheimer’s and Parkinson’s disease as well as some other neurological disorders1,2. The major known function of HLA-DR is to present foreign antigen to T-helper/inducer cells. In affected areas of Alzheimer’s disease brain, a significant number of T-lymphocytes have also been detected3, indicating that the appropriate tissue elements for a cell mediated immune response are present. The purpose of this study was to investigate the response of immune components to controlled sterile lesions to rat brain. Such information should contribute to understanding data obtained in human degenerative neurological diseases.


Major Histocompatibility Complex Major Histocompatibility Complex Class Kainic Acid Reactive Microglia GFAP Positive Astrocyte 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Haruhiko Akiyama
    • 1
  • Shigeru Itagaki
    • 2
  • Patrick L. McGeer
    • 1
  • Edith G. McGeer
    • 1
  1. 1.Kinsmen Laboratory of Neurological Research, Department of PsychiatryUniversity of British ColumbiaVancouverCanada
  2. 2.Department of NeuropsychiatryFukushima Medical CollegeFukushimaJapan

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