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Basement Membrane Components in Alzheimer’s Disease

  • Kazuo Shigematsu
  • Hisaki Kamo
  • Shinichi Nakamura
  • Ichiro Akiguchi
  • Jun Kimura
  • Fukashi Udaka
  • Masakuni Kameyama
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Characteristic features in dementia of Alzheimer type (DAT) include senile plaques, neurofibrillary changes and alterations of basement membrane components, although the changes may be either primary or secondary to neuronal degeneration or other pathologies. Laminin (LA) and type IV collagen (CO) are basement membrane components (Timple et al., 1979). A high laminin immunoreactivity has been reported in newly formed vessels in developing tissues, neural grafts (Shigematsu et al., 1989 a), in neoplasms and in excitotoxin induced lesions (Shigematsu et al., 1989 b). Therefore, immunohistochemistry using antibodies against LA or CO should be useful not only for demonstrating vascular structures in normal brains (Eriksdotter-Nilsson et al., 1986) but also for studying basement membrane alterations associated with various pathological changes. We have examined the immunoreactivity of the basement membrane components, LA and CO, in DAT brains.

Keywords

Amyotrophic Lateral Sclerosis Senile Plaque Senile Dementia Basement Membrane Component Central Nervous Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Kazuo Shigematsu
    • 1
  • Hisaki Kamo
    • 1
  • Shinichi Nakamura
    • 1
  • Ichiro Akiguchi
    • 1
  • Jun Kimura
    • 1
  • Fukashi Udaka
    • 2
  • Masakuni Kameyama
    • 2
  1. 1.Department of NeurologyKyoto UniversityKyotoJapan
  2. 2.Department of NeurologySumitomo HospitalOsakaJapan

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