Acetylcholinesterase Histochemical Changes in the Cerebral Cortex of Alzheimer’s Disease
A reduction in cortical choline acetyltransferase is one of the most widely demonstrated biochemical effects in Alzheimer’s disease (AD)1. Acetylcholinesterase (AChE), the degrading enzyme for acetylcholine, is also reduced2. By application of a sensitive method for AChE-histochemistry we have recently demonstrated a strong association of AChE-positive axons with senile plaques3.
KeywordsSenile Plaque Acetylthiocholine Iodide Choline Acetyl AChE Staining Amyloid Core
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