Acetylcholinesterase Histochemical Changes in the Cerebral Cortex of Alzheimer’s Disease

  • Hisao Tago
  • Yoshihiko Numata
  • Hisashi Kumashiro
  • Patrick L. McGeer
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


A reduction in cortical choline acetyltransferase is one of the most widely demonstrated biochemical effects in Alzheimer’s disease (AD)1. Acetylcholinesterase (AChE), the degrading enzyme for acetylcholine, is also reduced2. By application of a sensitive method for AChE-histochemistry we have recently demonstrated a strong association of AChE-positive axons with senile plaques3.


Senile Plaque Acetylthiocholine Iodide Choline Acetyl AChE Staining Amyloid Core 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hisao Tago
    • 1
  • Yoshihiko Numata
    • 2
  • Hisashi Kumashiro
    • 1
  • Patrick L. McGeer
    • 3
  1. 1.Department of NeuropsychiatryFukushima Medical CollegeJapan
  2. 2.Department of Psychiatry and NeurologyFukushima Red Cross HospitalFukushimaJapan
  3. 3.Kinsmen Laboratory of Neurological Research, Department of PsychiatryUniversity of British ColumbiaCanada

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