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Protease Inhibitor and Cholinergic System in Alzheimer’s Disease

  • Shigenobu Nakamura
  • Seigo Tanaka
  • Wataru Araki
  • Teruyuki Tsuji
  • Shingo Kawashima
  • Satoshi Shiojiri
  • Yasuyuki Takahashi
  • Nobuya Kitaguchi
  • Hirataka Ito
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The level of mRNA for an amyloid precursor (APP770) containing a Kunitz-type trypsin inhibitor (PI) is elevated in the autopsied Alzheimer brain.1 However, the physiological significance of the augumented APP770 production has not been clarified thus far.

Keywords

AChE Activity Senile Plaque Supernatant Solution AChE Inhibitor Sucrose Density Gradient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shigenobu Nakamura
    • 1
  • Seigo Tanaka
    • 1
  • Wataru Araki
    • 1
  • Teruyuki Tsuji
    • 1
  • Shingo Kawashima
    • 1
  • Satoshi Shiojiri
    • 2
  • Yasuyuki Takahashi
    • 2
  • Nobuya Kitaguchi
    • 2
  • Hirataka Ito
    • 2
  1. 1.Department of Neurology, Faculty of MedicineKyoto UniversityKyotoJapan
  2. 2.Bio-science Laboratory, Life Science Research LaboratoriesAsahi Chemical Co., Ltd.FujiJapan

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