Alzheimer - Parkinson Disease Spectrum and Diffuse Lewy Body Disease

  • Dennis W. Dickson
  • Howard Crystal
  • Shu-Hui Yen
  • Peter Davies
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Diffuse Lewy body disease (DLBD) is a recently recognized primary degenerative dementia that shares pathological features with Alzheimer's disease (AD) and with Parkinson's disease (PD) (5,6,10–13,16). Clinically, it is difficult to diagnose DLBD (2) and most patients come to autopsy with a diagnosis of AD or less commonly progressive supranuclear palsy (5), because of rigidity and axial dystonia in some patients, or CreutzfeldtJacob disease, because of myoclonus or periodic complexes on electroencephalograms in some patients (18). In the majority of subjects, cognitive decline overshadows motor abnormalities. Despite degeneration in the substantia nigra and diencephalon that is indistinguishable from PD, some patients have had no apparent extrapyramidal features.


Lewy Body Senile Plaque Progressive Supranuclear Palsy Lewy Body Dementia Diffuse Lewy Body Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bancher C, Lassmann H, Budka H, et al. (1989) An antigenic profile of Lewy bodies: immunocytochemical indication for protein phsophorylation and ubiquitination. J Neuropathol Exp Neurol 48: 81–93PubMedCrossRefGoogle Scholar
  2. 2.
    Burkhardt CR, Filley CM, Kleinschmidt-DeMasters BK, et al. (1988) Diffuse Lewy body disease and progressive dementia. Neurology 38: 1520–1528PubMedCrossRefGoogle Scholar
  3. 3.
    Dickson DW, Farlo J, Davies P, et al. (1988) Alzheimer’s disease: a double-labeling immunohisto-chemical study of senile plaques. Am J Pathol 132: 86–101PubMedGoogle Scholar
  4. 4.
    Dickson DW, Farlo J, Yen SH, et al. (1988) Clinico-pathologic and immunocytochemical studies on demented and nondemented individuals distinguishes two classes of senile plaques (abstract). J Neuropathol Exp Neurol 47: 381Google Scholar
  5. 5.
    Dickson DW, Davies P, Mayeux R, et al. (1987) Diffuse Lewy body disease: neuro-pathological and biochemical studies of six patients. Acta Neuropathol (Berl) 75: 8–15CrossRefGoogle Scholar
  6. 6.
    Dickson DW, Crystal H, Mattiace L, et al. (1989) Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques. Acta Neuropathol 78: 572–584, 1989.Google Scholar
  7. 7.
    Dickson DW, Wertkin A, Mattiace LA, et al. (1990) Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer’s disease. Acta Neuropathol (in press)Google Scholar
  8. 8.
    Ditter SM, Mirra SS (1987) Neuropathologie and clinical features of Parkinson’s disease in Alzheimer’s disease patients. Neurology 37: 754–760PubMedCrossRefGoogle Scholar
  9. 9.
    Gaspar P, Gray F (1984) Dementia in idiopathic Parkinson’s disease: A neuropathological study of 32 cases. Acta Neuropathol 64: 43–52PubMedCrossRefGoogle Scholar
  10. 10.
    Gibb WRG, Esiri MM, Lees AJ (1987) Clinical and pathological features of diffuse cortical Lewy body disease ( Lewy body dementia ). Brain 110: 1131–1153Google Scholar
  11. 11.
    Hansen LA, Masliah E, Terry RD, et al. (1989) A neuropathological subset of Alzheimer’s disease with concommitant Lewy body disease and spongioform change. Acta Neuropathol 78: 194–201PubMedCrossRefGoogle Scholar
  12. 12.
    Kosaka K, Yoshimura M, Ikeda K, et al. (1984) Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree–a new disease? Clin Neuropathol 3: 185–192PubMedGoogle Scholar
  13. 13.
    Kosaka K, Tsuchiya K, Yoshimura M (1988) Lewy body disease with and without dementia: A clinicopathologic study of 35 cases. Clin Neuropathol 7: 299–305PubMedGoogle Scholar
  14. 14.
    Kuzuhara S, Mori H, Izumiyama N, et al. (1988) Lewy bodies are ubiquitinated: a light and electron microscopic immunocytochemical study. Acta Neuropathol 75: 345–353PubMedCrossRefGoogle Scholar
  15. 15.
    Leverenz J, Sumi M (1986) Parkinson’s disease in patients with Alzheimer’s disease. Arch Neurol 43: 662–664PubMedCrossRefGoogle Scholar
  16. 16.
    Sima AAF, Clark AW, Sternberger NA, et al. (1986) Lewy body dementia without Alzheimer changes. Can J Neurol Sci 13: 490–497PubMedGoogle Scholar
  17. 17.
    Wolozin BL, Pruchnicki A, Dickson DW, et al. (1986) A neuronal antigen in the brain of Alzheimer patients. Science 232: 648–650PubMedCrossRefGoogle Scholar
  18. 18.
    Yamamoto T, Imai T (1988) A case of diffuse Lewy body and Alzheimer’s diseases with periodic synchronous discharges. J Neuropathol Exp Neurol 47: 536–548Google Scholar
  19. 19.
    Yen S-H, Dickson DW, Peterson C, et al. (1986) Cytoskeletal abnormalities in neuropathology. In: EM Zimmerman (ed) Progress in neuropathology; vol. 6. Raven Press, New York, pp 63–90Google Scholar
  20. 20.
    Yoshimura N, Yoshimura I, Asada M, et al. (1988) Juvenile Parkinson’s disease with widespread Lewy bodies in the brain. Acta Neuropathol 77: 213–218PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Dennis W. Dickson
    • 1
  • Howard Crystal
    • 1
  • Shu-Hui Yen
    • 1
  • Peter Davies
    • 1
  1. 1.Departments of Pathology (Neuropathology) and NeurologyAlbert Einstein College of MedicineBronxUSA

Personalised recommendations