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Characteristics of Reactive Microglia in Alzheimer’s and Parkinson’s Disease Brain Tissue

  • Shigeru Itagaki
  • Haruhiko Akiyama
  • Patrick L. McGeer
  • Edith G. McGeer
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The brain has been believed to have an immunologically privileged status. Factors such as the absence of a lymphatic drainage, the restricted entry of globulins through the blood-brain barrier and a high tolerance to grafts appear to account for this view1. We suggest that brain responds in an appropriate fashion to immunological challenge and that microglia are resident representatives of the immune system. These cells express major histocompatibility complex (MHC) molecules, which are cell surface glycoproteins that play a significant role in the immune response. T-lymphocytes can interact only with cells expressing such MHC molecules. In Alzheimer’s and Parkinson’s disease brain, reactive microglia express the MHC class II molecule, HLA-DR2,3. HLA-DR is the major MHC glycoprotein involved in foreign antigen presentation to T helper/inducer lymphocytes.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Senile Plaque Major Histocompatibility Complex Molecule Double Immunostaining 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shigeru Itagaki
    • 1
  • Haruhiko Akiyama
    • 2
  • Patrick L. McGeer
    • 2
  • Edith G. McGeer
    • 2
  1. 1.Department of NeuropsychiatryFukushima Medical CollegeFukushimaJapan
  2. 2.Kinsmen Laboratory of Neurological Rsearch, Department of PsychiatryUniversity of British ColumbiaVancouverCanada

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