Choline Acetyltransferase and Substance P Level in Alzheimer’s Disease and Multi-Infarct Dementia

  • Tsukasa Sakurada
  • Agneta Nordberg
  • Bengt Winblad
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Neurochemical studies on dementia of Alzheimer type (SDAT) have indicated changes not only in the cholinergic system but also an involvement of other transmitters such as those of the noradrenergic, dopaminergic, and serotonergic systems. For substance P the results have not been consistent, though both decreased and unchanged levels of substance P have been reported. The purpose of this study was to measure substance P-like immunoreactivity and choline acetyltransferase activity in brains from SDAT patients and from patients with multi-infarct dementia (MID).


Muscarinic Receptor Homovanillic Acid ChAT Activity Neurochemical Study Choline Acetyltransferase Activity 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tsukasa Sakurada
    • 1
  • Agneta Nordberg
    • 2
  • Bengt Winblad
    • 3
  1. 1.Department of PharmacologyTohoku College of PharmacySendaiJapan
  2. 2.Department of PharmacologyUniversity of UppsalaUppsalaSweden
  3. 3.Department of Geriatric MedicineKarolinska InstituteSweden

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