Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia in middle and late life. Among the histologic features found in AD, Alzheimer’s neurofibrillary tangles (NFTs) are present in great profusion in the cerebral cortex with relative sparing of the occipital lobe and paracentral gyri, and are present in the basal nucleus of Meynert (bnM), hypothalamus, and tegmental nuclei of the rostral brain stem. Morphometric studies revealed loss of neurons in these areas.
KeywordsNerve Growth Factor Progressive Supranuclear Palsy Progressive Supranuclear Palsy Basal Nucleus Nuclear Area
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- 3.Oyanagi, K., Takahashi, H., Wakabayashi, K., and Ikuta, F., Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer’s disease, Brain Research (in press).Google Scholar