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Large Neurons in the Neostriatum and Basal Nucleus of Meynert: Simultaneous Decrease in Alzheimer’s Disease

  • Kiyomitsu Oyanagi
  • Hitoshi Takahashi
  • Kouichi Wakabayashi
  • Fusahiro Ikuta
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Alzheimer’s disease (AD) is the most common cause of dementia in middle and late life. Among the histologic features found in AD, Alzheimer’s neurofibrillary tangles (NFTs) are present in great profusion in the cerebral cortex with relative sparing of the occipital lobe and paracentral gyri, and are present in the basal nucleus of Meynert (bnM), hypothalamus, and tegmental nuclei of the rostral brain stem. Morphometric studies revealed loss of neurons in these areas.

Keywords

Nerve Growth Factor Progressive Supranuclear Palsy Progressive Supranuclear Palsy Basal Nucleus Nuclear Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Oyanagi, K., Takahashi, H., Wakabayashi, K., and Ikuta, F., 1987, Selective involvement of large neurons in the neostriatum of Alzheimer’s disease and senile dementia: a morphometric investigation, Brain Research, 411: 205–211.PubMedCrossRefGoogle Scholar
  2. 2.
    Oyanagi, K., Takahashi, H., Wakabayashi, K., and Ikuta, F., 1988, Selective decrease of large neurons in the neostriatum in progressive supranuclear palsy, Brain Research, 458: 218–223.PubMedCrossRefGoogle Scholar
  3. 3.
    Oyanagi, K., Takahashi, H., Wakabayashi, K., and Ikuta, F., Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer’s disease, Brain Research (in press).Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Kiyomitsu Oyanagi
    • 1
  • Hitoshi Takahashi
    • 1
  • Kouichi Wakabayashi
    • 1
  • Fusahiro Ikuta
    • 1
  1. 1.The Center for Materials of Brain Diseases and Department of Pathology, Brain Research InstituteNiigata UniversityNiigata 951Japan

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