Senile Changes in the Human Olfactory Bulbs
Little attention has been paid to the morphological changes in the olfactory bulbs in patients with dementia of the Alzheimer type, despite the fact that rhinencephalo-limbic structures, which receive fibers directly from the olfactory bulbs, are known to be severely affected.1–4 Recently, Pearson et al.4 raised the possibility that the olfactory tracts provide a portal of entry to the brain for any putative pathogenic agent(s) that induces senile plaque formation and/or Alzheimer’s neurofibrillary tangles (NFT).
KeywordsOlfactory Bulb Senile Plaque Cerebral Amyloid Angiopathy Alzheimer Type Mitral Cell
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- 3.K. Okamoto, M. Morimatsu, M. Shoji, S. Hirai, and M. Takatama, Senile changes in the human olfactory bulbs, Clin. Neurol. 26: 270 (1986).Google Scholar
- 7.D. M. A. Mann, C. M. Tucker, and P. 0. Yates, Alzheimer’s disease: An olfactory connection? in: “Mechanisms of Ageing and Development”, Elsevier Scientific Publishers, Ireland, 42:1 (1988).Google Scholar