Senile Changes in the Human Olfactory Bulbs

  • Koichi Okamoto
  • Shunsaku Hirai
  • Mikio Shoji
  • Masamitsu Takatama
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Little attention has been paid to the morphological changes in the olfactory bulbs in patients with dementia of the Alzheimer type, despite the fact that rhinencephalo-limbic structures, which receive fibers directly from the olfactory bulbs, are known to be severely affected.1–4 Recently, Pearson et al.4 raised the possibility that the olfactory tracts provide a portal of entry to the brain for any putative pathogenic agent(s) that induces senile plaque formation and/or Alzheimer’s neurofibrillary tangles (NFT).


Olfactory Bulb Senile Plaque Cerebral Amyloid Angiopathy Alzheimer Type Mitral Cell 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Koichi Okamoto
    • 1
  • Shunsaku Hirai
    • 1
  • Mikio Shoji
    • 1
  • Masamitsu Takatama
    • 2
  1. 1.Department of NeurologyGunma University School of MedicineJapan
  2. 2.Geriatrics Research Institute and HospitalGunma-kenJapan

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