Importance of 1-Methyltetrahydroisoquinoline (1MeTIQ) in Parkinson’s Disease
The existence of endogenous 1-methyl-l,2,3,4-tetrahydro-isoquinoline (1MeTIQ) accompanied with 1,2,3,4-tetrahydro-isoquinoline (TIQ) in the rat brain has been confirmed in our previous research.1 The possibility of TIQ and 1MeTIQ intake from some foods was also pointed out.2 Recently, the neurotoxic properties of TIQ have been discussed, especially with regard to Parkinson’s disease.3–7 In spite of structural similarity to TIQ, there has been no study for the role of 1MeTIQ, the structure of which is shown in Fig. 1, in Parkinson’s disease, except for our work that confirmed a decrease in 1MeTIQ content in parkinsonian brain.8
KeywordsTyrosine Hydroxylase Endogenous Substance Pole Test Normal Human Brain Intracerebral Microdialysis
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- 8.S. Ohta, M. Kohno, Y. Makino, O. Tachikawa, and M. Hirobe, Tetrahydroisoquinoline and 1-methyltetrahydroisoquinoline are present in the human brain: relation to Parkinson’s disease, Biomed. Res. 8: 453 (1987).Google Scholar