After 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was discovered to cause parkinsonism in humans, monkeys, and mice,1–2 Nagatsu et al. screened various compounds structurally similar to MPTP for neurotoxicity by assaying the inhibition of tyrosine hydroxylase activity in tissue slices of striatum in situ, and found that both pyridinium and phenyl rings were essential for the effects and that N-methyl-1,2,3,4-tetrahydroisoquinoline (N-Me-TIQ) and 1,2,3,4-tetrahydroisoquinoline (TIQ) could be candidates of endogenous or environmental factors that cause Parkinson’s disease.3
- Tyrosine Hydroxylase
- Normal Human Brain
- Tyrosine Hydroxylase Activity
- Parkinsonian Brain
- Double Focus Mass Spectrometer
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© 1990 Plenum Press, New York
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Niwa, T., Yoshizumi, H., Takeda, N., Tatematsu, A., Matsuura, S., Nagatsu, T. (1990). Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_63
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