Detection of Tetrahydroisoquinoline, a Parkinsonism-Related Compound, in Parkinsonian Brains and Foods by Gas Chromatography-Mass Spectrometry
Part of the
Advances in Behavioral Biology
book series (ABBI, volume 38A)
After 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was discovered to cause parkinsonism in humans, monkeys, and mice,1–2 Nagatsu et al. screened various compounds structurally similar to MPTP for neurotoxicity by assaying the inhibition of tyrosine hydroxylase activity in tissue slices of striatum in situ, and found that both pyridinium and phenyl rings were essential for the effects and that N-methyl-1,2,3,4-tetrahydroisoquinoline (N-Me-TIQ) and 1,2,3,4-tetrahydroisoquinoline (TIQ) could be candidates of endogenous or environmental factors that cause Parkinson’s disease.3
KeywordsTyrosine Hydroxylase Normal Human Brain Tyrosine Hydroxylase Activity Parkinsonian Brain Double Focus Mass Spectrometer
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Plenum Press, New York 1990