Amyloid β Protein Precursors having Proteinase Inhibitor Regions are Highly Expressed in Alzheimer’s Disease Brains

  • Nobuya Kitaguchi
  • Yasuyuki Takahashi
  • Yasuo Tokushima
  • Kiyomi Oishi
  • Satoshi Shiojiri
  • Seigo Tanaka
  • Shigenobu Nakamura
  • Hirataka Ito
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the aged and is characterized by cerebral deposits of amyloid β -protein (β -AP) comprising about 40 amino acids as senile plaque core and vascular amyloid.1,2 Since there is a correlation between the number of plaques and the degree of dementia, 3 it has been suggested that the formation of senile plaque is one of the pathogenetic features of AD. A complementary DNA (cDNA) clone of a β-AP precursor (APP) has been proved to encode a 695-amino acid precursor (APP695) having structural features characteristic of cell surface glycoproteins.4


Amyloid Precursor Protein Leukocyte Elastase Amyloid Protein Precursor mRNA Protease Nexin Proteinase Inhibitor Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Nobuya Kitaguchi
    • 1
  • Yasuyuki Takahashi
    • 1
  • Yasuo Tokushima
    • 1
  • Kiyomi Oishi
    • 1
  • Satoshi Shiojiri
    • 1
  • Seigo Tanaka
    • 2
  • Shigenobu Nakamura
    • 2
  • Hirataka Ito
    • 1
  1. 1.Bio-Science Laboratory, Life Science Research LaboratoriesAsahi Chemical Industry Co. Ltd.Fuji-Shi Shizuoka 416Japan
  2. 2.Department Neurology, Faculty of MedicineKyoto UniversitySakyo-ku, Kyoto 606Japan

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