Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the aged and is characterized by cerebral deposits of amyloid β -protein (β -AP) comprising about 40 amino acids as senile plaque core and vascular amyloid.1,2 Since there is a correlation between the number of plaques and the degree of dementia, 3 it has been suggested that the formation of senile plaque is one of the pathogenetic features of AD. A complementary DNA (cDNA) clone of a β-AP precursor (APP) has been proved to encode a 695-amino acid precursor (APP695) having structural features characteristic of cell surface glycoproteins.4
Keywords
- Amyloid Precursor Protein
- Leukocyte Elastase
- Amyloid Protein Precursor mRNA
- Protease Nexin
- Proteinase Inhibitor Domain
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Kitaguchi, N. et al. (1990). Amyloid β Protein Precursors having Proteinase Inhibitor Regions are Highly Expressed in Alzheimer’s Disease Brains. In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_6
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_6
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