Acute Effects of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) on Body Temperature of Various Strains of Mice
Systemic administration of the neurotoxin MPTP to experimental animals induces the selective destruction of the nigrostriatal dopamine (DA) system. This MPTP-induced toxicity requires conversion of MPTP to its active metabolite, 1-methyl-4-phenylpyridine (MPP+), by the mitochondrial enzyme monoamine oxidase B-form (MAO-B).1 This selective MPTP neurotoxicity is accounted for by active MPP+ accumulation into DA neurons via the high affinity DA uptake system.1 The mitochondria, in addition to being the site for MPP+ formation, may also be an important target of MPP neurotoxicity, since MPP+ inhibits mitochondrial respiration, resulting in prevention of ATP formation with consequent cell death in the DA system. The MPTP-treated primates represent the best model currently available for study of the etiology of Parkinson’s disease.
KeywordsC57BL Mouse Hypothermic Effect MPTP Administration MPTP Injection Dopaminergic Neurotoxicity
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