Effects of Various Drugs on Behavior and Striatal Dopamine Contents in MPTP-Treated Mice Exposed to Stress
Although the symptoms of patients with Parkinson’s disease are worsened by various stresses, a phenomenon known as stress-induced akinesia1,2 the pathophysiology and therapy of stress-induced akinesia has not been clarified. When the stress is mild, symptoms are easily improved by an increase in the dosage of 1–3,4-dihydroxyphenylalanine (L-DOPA). However, when patients with Parkinson’s disease are exposed to severe and long-term stress and the symptoms are highly aggravated, L-DOPA treatment is less effective. We previously reported that, due to a decreased dopamine (DA) level and enhancement of DA turnover, 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine (MPTP)-treated mice became remarkably akinetic after stress3 and that imipramine (IMP) and diazepam (DZP) were clinically more effective than L-DOPA in improving the condition.4
KeywordsLocomotor Activity Stress Group Pretreated Group Gastric Mucosal Lesion Acute Gastric Mucosal Lesion
Unable to display preview. Download preview PDF.
- 4.S. Nishikawa, K. Urakami, K. Shimoda, C. Hikasa, K. Takahashi, Effect of stress in Parkinson’s disease: Clinical and experimental study. Annual report of research committee of CNS of Japan, pp. 198–200 (1987).Google Scholar
- 6.G. S. Mayer, R. E. Shoup, Simultaneously multiple electrode liquid chromatographic-electrochemical assay for catecholamines, indoleamines, and metabolites in brain tissue, J. Chromatogr. 255: 533–544 (1967).Google Scholar