Abstract
Systemically administered 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP), a toxin inducing parkinsonism, is biotransformed into 1methyl-4-.phenylpyridinium ion (MPP+), which then enters dopaminergic neurons via the dopamine uptake system to destroy nigral cells.
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References
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© 1990 Plenum Press, New York
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Imai, H., Nakamura, T., Endo, K., Narabayashi, H. (1990). Hemiparkinsonism in Monkeys After Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP). In: Nagatsu, T., Fisher, A., Yoshida, M. (eds) Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases. Advances in Behavioral Biology, vol 38A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5844-2_56
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DOI: https://doi.org/10.1007/978-1-4684-5844-2_56
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5846-6
Online ISBN: 978-1-4684-5844-2
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