Hemiparkinsonism in Monkeys After Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)
Systemically administered 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP), a toxin inducing parkinsonism, is biotransformed into 1methyl-4-.phenylpyridinium ion (MPP+), which then enters dopaminergic neurons via the dopamine uptake system to destroy nigral cells.
KeywordsTyrosine Hydroxylase Substantia Nigra Caudate Nucleus Locus Ceruleus Osmotic Minipump
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