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Hemiparkinsonism in Monkeys After Unilateral Striatum Infusion of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)

  • Hisamasa Imai
  • Toshiki Nakamura
  • Kiyonori Endo
  • Hirotaro Narabayashi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Systemically administered 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP), a toxin inducing parkinsonism, is biotransformed into 1methyl-4-.phenylpyridinium ion (MPP+), which then enters dopaminergic neurons via the dopamine uptake system to destroy nigral cells.

Keywords

Tyrosine Hydroxylase Substantia Nigra Caudate Nucleus Locus Ceruleus Osmotic Minipump 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Imai, H., Nakamura, T., Endo, K. and Narabayashi, H., 1988, Hemiparkin-sonism in monkeys after unilateral caudate nucleus infusion of 1methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): behavior and histology, Brain Res., 474: 327.CrossRefGoogle Scholar
  2. Langston, J.W. and Irwin, I., 1986, MPTP: current concepts and controversies, Clin. Neuropharmacol., 9: 485.Google Scholar
  3. Nagatsu, T., Oka, K. and Kato, T., 1979, Highly sensitive assay for tyrosine hydroxylase activity by high performance liguid chromatography, J. Chromatogr., 163: 247.PubMedCrossRefGoogle Scholar
  4. Snyder, S.H. and D’Amato, R.J., 1986, MPTP: a neurotoxin relevant to the pathophysiology of Parkinson’s disease, Neurology, 36: 250.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hisamasa Imai
    • 1
  • Toshiki Nakamura
    • 1
  • Kiyonori Endo
    • 1
  • Hirotaro Narabayashi
    • 1
  1. 1.Department of NeurologyJuntendo University School of MedicineTokyoJapan

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