L-DOPA-Induced Facilitation of Dopamine Release VIA Presynaptic β-Adrenoceptors in Striatal Slices from MPTP-Treated C57BL Mice: Evaluation of the Action of L-DOPA in Animal Model for Parkinsonism

  • Yoshio Goshima
  • Yoshimi Misu
  • Nobutaka Arai
  • Kazuaki Misugi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

L-3,4-Dihydroxyphenylalanine (DOPA) is the most effective therapeutic agent for Parkinson’s disease and is believed to act exclusively via its conversion to dopamine (DA). However, we proposed that DOPA itself may act as an endogenous neuroactive substance.1–3 To asses this proposal, we employed 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-treated C57 black (BL) mice as a model for parkinsonism, and examined the effect of L-DOPA in this system by observing striatal slices from these animals.

Keywords

Dopamine Noradrenaline Catecholamine Propranolol MPTP 

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Yoshio Goshima
    • 1
  • Yoshimi Misu
    • 1
  • Nobutaka Arai
    • 2
  • Kazuaki Misugi
    • 2
  1. 1.Departments of PharmacologyYokohama City University School of MedicineYokohama 236Japan
  2. 2.Departments of PathologyYokohama City University School of MedicineYokohama 236Japan

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