Advertisement

Mitochondrial Abnormalities in the Nigral Neurons of Crab-Eating Monkeys with Experimental Parkinsonism

  • Junichi Tanaka
  • Haruomi Nakamura
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Experimental parkinsonism has been induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1,2,3,4-tetrahydroisoquinoline (TIQ) in several primates, and leads to an animal model of Parkinson’s disease.1–4 The pathological change observed in the MPTP-treated monkeys is selective neuronal damage in the substantia nigra. Neurotoxic effects of MPTP on the nigral neurons are possibly due to inhibition of mitochondrial oxidation by some MPTP metabolite.3 The detailed pathomechanism of mitochondrial abnormalities, however, remains ill defined.

Keywords

Amyotrophic Lateral Sclerosis Tyrosine Hydroxylase Substantia Nigra Mitochondrial Abnormality Nigral Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    R. S. Burns, C. C. Chiueh, S. P. Markey, and M. H. Ebert, A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine, Proc. Nati. Acad. Sci. USA. 80: 4546 (1983).CrossRefGoogle Scholar
  2. 2.
    J. W. Langston, L. S. Forno, C. S. Rebert, and I. Irwin, Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP) in the squirrel monkey, Brain Res. 292: 390 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    J. Tanaka, H. Nakamura, S. Honda, K. Takada, and S. Kato, Neuro-pathological study on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of the crab-eating monkey, Acta Neuropathol. 77: 489 (1988).Google Scholar
  4. 4.
    T. Nagatsu and M. Yoshida, An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostrial regions, Neurosci. Lett. 87: 178 (1988).PubMedCrossRefGoogle Scholar
  5. 5.
    J. W. Langston, I. Irwin, E. B. Langston, and L. S. Forno, 1-Methyl4-phenyl-1,2,3,6-tetrahydropyridinium ion (MPP+): identification of a metabolite of MPTP, a toxin selective to the substantia nigra, Neurosci. Lett. 48: 87 (1984).PubMedCrossRefGoogle Scholar
  6. 6.
    B. F. Trump, E. M. McDowell, and A. U. Austila, Cellular reaction to injury, in: “Principle of pathobiology”, R. B. Hill and M. F. LaVia, eds., Oxford Univ. Press, New York (1980).Google Scholar
  7. 7.
    W. J. Nicklas, I. Vyas, and R. E. Heikkila, Inhibition of NAD-linked oxidation in brain mitochondria by 1-methyl-4-phenylpyridine, a metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Life Sci. 36: 2503 (1985).PubMedCrossRefGoogle Scholar
  8. 8.
    H. Nakamura, S. Kato, and J. Tanaka, Mitochondria covered with a net of parallel and latticed filaments in nigral neurons of monkeys with experimental parkinsonism, Acta Neuropathol. 77: 489 (1989).PubMedCrossRefGoogle Scholar
  9. 9.
    A. Hirano, H. Donnenfeld, A. Sasaki, and I. Nakano, Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis, J. Neuropathol. Exp. Neurol. 43: 461 (1984)PubMedCrossRefGoogle Scholar
  10. 10.
    M. Kohno, S. Ohta, and M. Hirobe, Tetrahydroisoquinoline and 1methyl-tetrahydroisoquinoline as a novel endogenous amines in rat brain, Biochem. Biophys. Res. Commun. 140: 448 (1986).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Junichi Tanaka
    • 1
  • Haruomi Nakamura
    • 2
  1. 1.Divisions of NeuropathologyJikei University School of MedicineTokyoJapan
  2. 2.Divisions of NeuropathologyTottori University School of MedicineYonagoJapan

Personalised recommendations