Mitochondrial Abnormalities in the Nigral Neurons of Crab-Eating Monkeys with Experimental Parkinsonism
Experimental parkinsonism has been induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1,2,3,4-tetrahydroisoquinoline (TIQ) in several primates, and leads to an animal model of Parkinson’s disease.1–4 The pathological change observed in the MPTP-treated monkeys is selective neuronal damage in the substantia nigra. Neurotoxic effects of MPTP on the nigral neurons are possibly due to inhibition of mitochondrial oxidation by some MPTP metabolite.3 The detailed pathomechanism of mitochondrial abnormalities, however, remains ill defined.
KeywordsAmyotrophic Lateral Sclerosis Tyrosine Hydroxylase Substantia Nigra Mitochondrial Abnormality Nigral Neuron
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