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Enzymological Aspects of the Actions of the Parkinsonism-Inducing Neurotoxin MPTP

  • James P. Sullivan
  • John M. McCrodden
  • Keith F. Tipton
Chapter
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The role of the B-form of monoamine oxidase (MAO-B) in converting the compound MPTP (1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine) to neurotoxic metabolites is well-established from studies on the protection afforded by selective inhibitors of that enzyme (for reviews see Singer et al., 1987; Kinemuchi et al., 1987). The neurotoxic metabolite appears to be the 4-electron oxidation product, the 4-phenylpyridinium ion (MPP(+)). It has been proposed that the action of this compound as an inhibitor of mitochondrial oxidative phosphorylation from NADH may account for its neurotoxicity (Nicklas et al., 1985; Ramsay et al., 1986).

Keywords

Monoamine Oxidase Brain Mitochondrion Mitochondrial Oxidative Phosphorylation Partition Ratio Deuterium Isotope Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • James P. Sullivan
    • 1
  • John M. McCrodden
    • 1
  • Keith F. Tipton
    • 1
  1. 1.Department of BiochemistryTrinity CollegeDublin 2Ireland

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