Enzymological Aspects of the Actions of the Parkinsonism-Inducing Neurotoxin MPTP

  • James P. Sullivan
  • John M. McCrodden
  • Keith F. Tipton
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


The role of the B-form of monoamine oxidase (MAO-B) in converting the compound MPTP (1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine) to neurotoxic metabolites is well-established from studies on the protection afforded by selective inhibitors of that enzyme (for reviews see Singer et al., 1987; Kinemuchi et al., 1987). The neurotoxic metabolite appears to be the 4-electron oxidation product, the 4-phenylpyridinium ion (MPP(+)). It has been proposed that the action of this compound as an inhibitor of mitochondrial oxidative phosphorylation from NADH may account for its neurotoxicity (Nicklas et al., 1985; Ramsay et al., 1986).


Monoamine Oxidase Brain Mitochondrion Mitochondrial Oxidative Phosphorylation Partition Ratio Deuterium Isotope Effect 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • James P. Sullivan
    • 1
  • John M. McCrodden
    • 1
  • Keith F. Tipton
    • 1
  1. 1.Department of BiochemistryTrinity CollegeDublin 2Ireland

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