Complex I Deficiency in Parkinson’s Disease and MPTP-Induced Experimental Parkinsonism
It has been considered that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced parkinsonism is the best model available at present of Parkinson’s disease. Elucidation of the mechanism of the neuronal degeneration in this model will contribute to the studies on the pathogenesis of Parkinson’s disease. In this communication, we will present our data on the mechanism of the neuronal degeneration in MPTP-induced experimental parkinsonism and a preliminary observation on Parkinson’s disease.
KeywordsNeuronal Degeneration Mitochondrial Complex Hydrophobic Fraction Jichi Medical School Postmortem Period
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- 2.K. Chiba, A. J. Trevor and N. Castagnoli, Jr., Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes, Biochem. Biophys. Res. Commun., 128: 1229 (1984).Google Scholar
- 15.Y. Mizuno, S. Ohta, M. Tanaka, S. Takamiya, K. Suzuki, H. Oya, T. Ozawa and Y. Kagawa, Deficiencies in Complex I subunits of the respiratory chain in Parkinson’s disease, Biochem. Biophys. Res. Commun., (in press) (1989).Google Scholar