Monoclonal Antibodies Against Paired Helical Filament in Alzheimer’s Disease and Parkinsonism-Dementia Complex of Guam
Neurofibrillary tangles (NFT) are one of the most prominent pathological changes seen in the brains of Alzheimer’s disease (Alz) patients. Under the electron microscope these NFT are revealed to be composed of accumulations of paired helical filaments (PHF). These structures are also observed in Parkinsonism-dementia complex of Guam (PD), and some other diseases besides Alz.
KeywordsDown Syndrome Brain Homogenate Paired Helical Filament Paired Helical Filament Paraffin Embed Section
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