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Monoclonal Antibodies Against Paired Helical Filament in Alzheimer’s Disease and Parkinsonism-Dementia Complex of Guam

  • Y. Takamaru
  • T. Obara
  • R. Fukatsu
  • K. Tsuzuki
  • Y. Aizawa
  • M. Fujii
  • M. Kobayashi
  • T. Gotoda
  • R. Yanagihara
  • R. Garruto
  • K. Oguma
  • N. Takahata
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Neurofibrillary tangles (NFT) are one of the most prominent pathological changes seen in the brains of Alzheimer’s disease (Alz) patients. Under the electron microscope these NFT are revealed to be composed of accumulations of paired helical filaments (PHF). These structures are also observed in Parkinsonism-dementia complex of Guam (PD), and some other diseases besides Alz.

Keywords

Down Syndrome Brain Homogenate Paired Helical Filament Paired Helical Filament Paraffin Embed Section 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Y. Takamaru
    • 1
  • T. Obara
    • 1
  • R. Fukatsu
    • 2
  • K. Tsuzuki
    • 3
  • Y. Aizawa
    • 2
  • M. Fujii
    • 2
  • M. Kobayashi
    • 2
  • T. Gotoda
    • 1
  • R. Yanagihara
    • 4
  • R. Garruto
    • 4
  • K. Oguma
    • 3
  • N. Takahata
    • 2
  1. 1.Department of Psychiatry and NeurologyHokkaido UniversityJapan
  2. 2.Department of NeuropsychiatrySapporo Medical CollegeSapporoJapan
  3. 3.Department of MicrobiologySapporo Medical CollegeSapporoJapan
  4. 4.NIHBethesdaUSA

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