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An Early Change of Neurofibrillary Tangle Formation

  • Hidehiro Mizusawa
  • Shu-Hui C. Yen
  • Asao Hirano
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Neurofibrillary tangle (NFT) is a pathological hallmark of Alzheimer’s disease (1). NFT’s are fibrous masses in neuronal perikarya and proximal neurites, and usualy hematoxylinophilic on H&E stain and very argyrophilic on silver impregnation (intracellular tangles). They are not static lesions and show evolutionary changes from intracellular to extracellular location. Extracellular NFT’s are eosinophilic and less argyrophilic, and often are regarded as tombstones of neurons or ghost tangles (2,3). However, little has been known about initial changes of NFT formation. In this communication, we describe that there is an early change of NFT formation demonstrable by the modified Bielschowsky (Hirano) method.

Keywords

Neurofibrillary Tangle Paired Helical Filament Neuronal Perikaryon Diffuse Lewy Body Disease Immunoreactive Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hidehiro Mizusawa
    • 1
  • Shu-Hui C. Yen
    • 1
  • Asao Hirano
    • 1
  1. 1.Division of Neuropathology, Department of PathologyMontefiore Medical Center and Albert Einstein College of MedicineBronxUSA

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