An Early Change of Neurofibrillary Tangle Formation

  • Hidehiro Mizusawa
  • Shu-Hui C. Yen
  • Asao Hirano
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Neurofibrillary tangle (NFT) is a pathological hallmark of Alzheimer’s disease (1). NFT’s are fibrous masses in neuronal perikarya and proximal neurites, and usualy hematoxylinophilic on H&E stain and very argyrophilic on silver impregnation (intracellular tangles). They are not static lesions and show evolutionary changes from intracellular to extracellular location. Extracellular NFT’s are eosinophilic and less argyrophilic, and often are regarded as tombstones of neurons or ghost tangles (2,3). However, little has been known about initial changes of NFT formation. In this communication, we describe that there is an early change of NFT formation demonstrable by the modified Bielschowsky (Hirano) method.


Neurofibrillary Tangle Paired Helical Filament Neuronal Perikaryon Diffuse Lewy Body Disease Immunoreactive Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Alzheimer, A.: Über eigentartige Krankheitsfälle des späteren Alters. Z. ges. Neurol. Psych., 4: 356, 1911CrossRefGoogle Scholar
  2. 2.
    Okamoto, K., Hirano, A., Yamaguchi, H., and Hirai, S.: The fine structure of eosinophilic stages of Alzheimer’s neurofibrillary tangles. Clin. Neurol., 22: 840, 1982Google Scholar
  3. 3.
    Probst, A., Ulrich, J., and Heitz, U.: Senile dementia of Alzheimer type: astroglial reaction to extracellular neurofibrillary tangles in the hippocampus: an immuno-cytochemical and electron-microscopic study. Acta Neuropathol. (Berl.), 57: 75, 1982CrossRefGoogle Scholar
  4. 4.
    Yamamoto, T., and Hirano, A.: A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer’s neurofibrillary tangles. Neuropathol. Appl. Neurobiol., 12: 3, 1986PubMedCrossRefGoogle Scholar
  5. 5.
    Binder, L.I., Frankfurter, A., and Rebhun, L.I.: The distribution of tau in the mammalian central nervous system. J. Cell Biol., 101: 1371, 1985PubMedCrossRefGoogle Scholar
  6. 6.
    Bancher, C., Brunner, C., Lassmann, H., Budka, H., Jellinger, K., Wiche, G., Seitelberger, F., Grundke-Iqbal, I., Iqbal, K., and Wisiniewski, H.M.: Accumulation of abnormally phosphorylated Tprecedes the formation of neurofibrillary tangles in Alzheimer’s disease. Brain Res., 477: 90, 1989PubMedCrossRefGoogle Scholar
  7. 7.
    Papasozomenos, S.C.: Tau protein immunoreactivity in dementia of the Alzheimer type. II. Electron microscopy and pathogenetic implications. Effects of fixation on the morphology of the Alzheimer’s abnormal filaments. Lab. Invest., 60: 375, 1989PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hidehiro Mizusawa
    • 1
  • Shu-Hui C. Yen
    • 1
  • Asao Hirano
    • 1
  1. 1.Division of Neuropathology, Department of PathologyMontefiore Medical Center and Albert Einstein College of MedicineBronxUSA

Personalised recommendations