An Early Change of Neurofibrillary Tangle Formation
Neurofibrillary tangle (NFT) is a pathological hallmark of Alzheimer’s disease (1). NFT’s are fibrous masses in neuronal perikarya and proximal neurites, and usualy hematoxylinophilic on H&E stain and very argyrophilic on silver impregnation (intracellular tangles). They are not static lesions and show evolutionary changes from intracellular to extracellular location. Extracellular NFT’s are eosinophilic and less argyrophilic, and often are regarded as tombstones of neurons or ghost tangles (2,3). However, little has been known about initial changes of NFT formation. In this communication, we describe that there is an early change of NFT formation demonstrable by the modified Bielschowsky (Hirano) method.
KeywordsNeurofibrillary Tangle Paired Helical Filament Neuronal Perikaryon Diffuse Lewy Body Disease Immunoreactive Structure
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