Molecular Genetics of Alzheimer’s Disease

  • John Hardy
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


St. George Hyslop and colleagues (1987) reported that familial Alzheimer’s disease was caused by a locus on the long arm of chromosome 21. In a cohort of families with early onset of disorder (<60 years), we have confirmed this observation (Goate et al., 1989). However, two groups (Schellenberg et al., 1988, Pericak-Vance et al., 1988) have failed to find evidence of linkage to chromosome 21 in families they have studied. The purpose of this article is to discuss possible reasons for this discrepancy.


Late Onset TaqI Polymorphism XbaI Polymorphism Mental Health Foundation Small Pedigree 
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  1. J. Breitner et al. Familial aggregation in Alzheimer’s disease: comparison of risk between early and late onset cases and between male and female relatives in successive generations. Neurology 20: 207 (1988).CrossRefGoogle Scholar
  2. A.M. Goate et al. Predisposing locus for Alzheimer’s disease on chromosome 21. Lancet 1: 352 (1989).PubMedCrossRefGoogle Scholar
  3. J.A. Hardy et al. Modelling the occurrence and pathology of Alzheimer’s disease. Neurobiol. Agning 10: 429 (1989).CrossRefGoogle Scholar
  4. M.I. Olsson and C.M. Shaw. Presenile dementia and Alzheimer’s disease in mongolism. Brain 92: 147 (1969).CrossRefGoogle Scholar
  5. M.J. Owen et al. A pulsed field map around the Alzheimer’s disease locus on the proximal long arm of chromosome 21. Am. J. Hum. Genet. (in press).Google Scholar
  6. M.A. Pericak Vance et al. Genetic linkage studies in familial Alzheimer’s disease. Exp. Neurol. 102: 271 (1988).Google Scholar
  7. P. St. George Hyslop et al. The genetic defect causing Alzheimer’s disease maps on chromosome 21. Science 235: 885 (1987).CrossRefGoogle Scholar
  8. G.D. Schellenberg et al. Absence of linkage of chromosome 21q21 markers to familial Alzheimer’s disease. Science 241: 1507 (1988).PubMedCrossRefGoogle Scholar
  9. R. Tanzi et al. Genetic linkage map of chromosome 21. Genomics 3: 129 (1988).PubMedCrossRefGoogle Scholar
  10. C. Van Broeckhoven et al. in: “Genetics of Alzheimer’s Disease”. P.M. Sinet ed., Springer Verlag Press, Berling (1988).Google Scholar
  11. A. Walker et al. A jump clone from D21S16 recognises an informative RFLP. Nucl. Acids Res. (in press) (1990).Google Scholar
  12. A. Warren et al. A genetic linkage map of 17 markers on chromosome 21. Genomics 4: 579 (1989).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • John Hardy
    • 1
  1. 1.Department of Biochemistry and Molecular GeneticsSt. Mary’s Hospital Medical SchoolLondonEngland

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