Astroglial Gene Expression in the Hippocampus Following Partial Deafferentation in the Rat and in Alzheimer’s Disease
Astrocytes play important roles in the complex neuronal and glial response to brain injury and pathological neuronal loss. Also referred as gliosis, this process is usually characterized by extensive astroglial hypertrophy and proliferation. In addition, reactive astrocytes undergo numerous cytological, biochemical and histochemical changes, including accumulation of vimentin, glycogen, increased oxidoreductive enzyme activity and most notably, increased accumulation of glial fibrillary acidic protein (GFAP) (Bignami and Dahl, 1976). Reactive astrocytes appear to be involved in healing responses to neuron injury by scavenging myelin and neuronal debris (Lee et al., 1977) and by releasing soluble proteins in their microenvironment which often have neurotrophic properties.
KeywordsGlial Fibrillary Acidic Protein Differential Expressi Reactive Astrocyte Glial Fibrillary Acidic Protein Immunoreactivity Neurotrophic Property
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