Experimental Synaptic Degeneration as a Model for the Pathogenesis of Alzheimer’s Disease: Monoclonal Antibodies and a Protein Kinase Inhibitor Block Synapse Formation and Maintenance Between Cultured CNS Neurons
A “tracing circuit” model has been proposedl, where in neuronal circuits are maintained by activity-dependent elimination of ex-circuit synapses and resultant sprouting of in-circuit axonal terminals, a process that might corre pond to human memory. Since synaptic and neuronal degeneration2, even following abnor-mal synapse formation3,4, represents the possible pathogenesis of the dementia of Alzheimer’s disease, the search for unknown molecules involved in the maintenance and formation of synaptic contacts is a promising approach to understanding of the disease.
KeywordsSynaptic Contact Synapse Formation Protein Kinase Inhibitor Cerebral Cortical Neuron Hippocampal Neuron Culture
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