Some Findings on Intermediate Filaments in Alzheimer’s Disease

  • Tsuyoshi Nishimura
  • Masatoshi Takeda
  • Kazuko Nakamura
  • Junya Tanaka
  • Yu Nakamura
  • Takashi Kudo
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The aberration of cytoskeletal systems is speculated in the pathogenesis of Alzheimer’s disease (Selkoe,1989). In this present report, we communicate, 1) the presence of higher titers of IgG antibody against glial fibrillary acidic protein (GFAP) in Alzheimer sera than in control sera and further characterization of the lympocytes from Alzheimer patients, 2) aberration of vimentin fiber arrangement in Alzheimer fibroblasts, and 3) characterization ofneurofilament fibers observed in aluminum encephalopathy in rabbit brain. From these independent findings about intermediate filaments in the central nervous system, we also the author will discuss the possible involvement of intermediate filament aberration in Alzheimer pathogenesis.Ministry of Education of Japan.

Keywords

Formaldehyde Dementia Neurol Cyclosporin Paraformaldehyde 

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tsuyoshi Nishimura
    • 1
  • Masatoshi Takeda
    • 1
  • Kazuko Nakamura
    • 1
  • Junya Tanaka
    • 1
  • Yu Nakamura
    • 1
  • Takashi Kudo
    • 1
  1. 1.Department of NeuropsychiatryOsaka University Medical SchoolFukushimaFukushima, Osaka 553Japan

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