Some Findings on Intermediate Filaments in Alzheimer’s Disease
The aberration of cytoskeletal systems is speculated in the pathogenesis of Alzheimer’s disease (Selkoe,1989). In this present report, we communicate, 1) the presence of higher titers of IgG antibody against glial fibrillary acidic protein (GFAP) in Alzheimer sera than in control sera and further characterization of the lympocytes from Alzheimer patients, 2) aberration of vimentin fiber arrangement in Alzheimer fibroblasts, and 3) characterization ofneurofilament fibers observed in aluminum encephalopathy in rabbit brain. From these independent findings about intermediate filaments in the central nervous system, we also the author will discuss the possible involvement of intermediate filament aberration in Alzheimer pathogenesis.Ministry of Education of Japan.
KeywordsFormaldehyde Dementia Neurol Cyclosporin Paraformaldehyde
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