Some Findings on Intermediate Filaments in Alzheimer’s Disease
The aberration of cytoskeletal systems is speculated in the pathogenesis of Alzheimer’s disease (Selkoe,1989). In this present report, we communicate, 1) the presence of higher titers of IgG antibody against glial fibrillary acidic protein (GFAP) in Alzheimer sera than in control sera and further characterization of the lympocytes from Alzheimer patients, 2) aberration of vimentin fiber arrangement in Alzheimer fibroblasts, and 3) characterization ofneurofilament fibers observed in aluminum encephalopathy in rabbit brain. From these independent findings about intermediate filaments in the central nervous system, we also the author will discuss the possible involvement of intermediate filament aberration in Alzheimer pathogenesis.Ministry of Education of Japan.
KeywordsGlial Fibrillary Acidic Protein Intermediate Filament Paired Helical Filament Rabbit Brain Pokeweed Mitogen
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- Kingsley B.S.,Gaskin F.,and Fu S.M., Human antibodies to neurofibrillay tangles and astrocytes in Alzheimer’s disease.JNeuroimmunol 19: 89, (1988).Google Scholar
- Klatzo,I.,11isniewski H.,and Streicher E., Experimetnalproduction of neurofibrillary degeneration. J Neuropathol Exp Neurol 24:187,(1965).Google Scholar
- Lowe J.,Blanchard A.,Morrell K.,Lennox G.,Reynolds L.,Billett M.,Landon M.,and Mayer J., Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man,including those of Parkinson’s disease, Pick’s disease,and Alzheimer’s disease, as well as Rosenthal fibers in cerebellar astrocytomas,cytoplasmic bodies in muscle,and Mallory bodies in alcoholic liver disease. J Pathol 155: 9, (1988).Google Scholar
- Mori H.,Kondo J.,Ihara Y.,Ubiquitin is a component of paired helical filaments in Alzheimer’s disease. Science 235: 1641, (1987).Google Scholar
- Perry G.,Friedman R.,Shaw G.,Chau V.,Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brain.Proc.Natl.Acad.Sci.USA 84:3033, (1987).Google Scholar
- Selkoe D.J.,Biochemistry of altered brain proteins in Alzheimer’s disease. Ann Rev Neurosci 12: 463, (1989).Google Scholar
- Tanaka J.,Murakoshi K.,Takeda M.,Kato Y.,Tada K.,Hariguchi S.,and Nishimura T.,A high level of anti-GFAP autoantibody in the serum of patients with Alzheimer’s disease.Biomed Res 9:209,(1988).Google Scholar