β-Amyloid Plaques and Dementia: An Immunohistochemical Study

  • Shigeki Kuzuhara
  • Yasuo Ihara
  • Hiroyuki Shimada
  • Yasuo Toyokura
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Senile plaques (SPs) and NFTs were immunohistochemically studied in the temporal lobe of 246 autopsy brains from non-demented and demented old people, using antibodies to synthetic polypeptide (1–24) of β-protein of cerebrovascular amyloid and to human tau protein. Dementia was present in 64% of 28 cases with many NFTs, while it was present only 33% of 43 cases in which there were many SPs but a few NFTs. The rate of prevalence of β-immunoreactive SPs increased with age in both demented and non-demented subjects. It was not significantly different between non-demented group (40% of 161 cases), and senile (47% of 19 cases) or vascular (30% of 27 cases) dementia groups. These findings suggest that β-immunoreactive SPs may be related to aging but may not be closely linked to dementia.


Senile Plaque Senile Dementia Parahippocampal Gyrus Paired Helical Filament Paired Helical Filament 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shigeki Kuzuhara
    • 1
  • Yasuo Ihara
    • 3
  • Hiroyuki Shimada
    • 2
  • Yasuo Toyokura
    • 1
  1. 1.Department of NeurologyTokyo Metropolitan Geriatric HospitalJapan
  2. 2.Department of PathologyTokyo Metropolitan Geriatric HospitalJapan
  3. 3.Department of Clinical PhysiologyTokyo Metropolitan Institute of GerontologyTokyoJapan

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