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Monoamine Oxidase B Activity in Senile Plaque

  • Shinichi Nakamura
  • Osamu Yasuhara
  • Toshio Kawamata
  • Toru Kimura
  • Ichiro Akiguchi
  • Jun Kimura
  • Masakuni Kameyama
  • Noriko Nakamura
  • Hiroshi Kimura
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Two types of monoamine oxidase (MAO; EC 1.4.3.4), MAO-A and MAO-B, has been demonstrated on the basis of their inhibitor specificities and substrate preferences (Johnston, 1968; Knoll and Magyar, 1972; Glover et al., 1977; Fowler et al., 1980; Garrick and Murphy, 1980). The age related increment of MAO-B activity has been described in the various regions of human brain, including the neocortex, hippocampus, basal ganglia and amygdala (Adolfsson et al., 1980; Oreland and Gottfries, 1986). Increased MAO-B activity has also been shown in the neocortex and hippocampus of dementia of Alzheimer type (DAT) (Adolfsson et al., 1980; Oreland and Gottfries, 1986; Reinikainen et al., 1988).

Keywords

Glial Fibrillary Acidic Protein Monoamine Oxidase Senile Plaque Insular Cortex Postmortem Human Brain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adolfsson R., Gottfries C. -G., Oreland L., Wiberg A., and Winblad B., 1980, Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type, Life Sci., 27: 1029.Google Scholar
  2. Arai R., Kimura H., and Maeda T., 1986, Topographic atlas of monoamine oxidasecontaining neurons in the rat brain studied by an improved histochemical method, Neuroscience, 19: 905.PubMedCrossRefGoogle Scholar
  3. Beach T. G., Tago H., Nagai T., Kimura H., McGeer P. L., and McGeer E. G., 1987, Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation, J. Neurosci. Methods, 19: 183.Google Scholar
  4. Cross A. J., Crow T. J., Johnson J. A., Joseph M. H., Perry E. K., Perry R. H., Blessed G., and Tomlinson B. E., 1983, Monoamine metabolism in senile dementia of Alzheimer type, J. Neurol. Sci., 60: 383–392.Google Scholar
  5. Fowler C. J., Oreland L., Marcusson J., and Winblad B., 1980, Titration of human brain monoamine oxidase -A and -B by clorgyline and L-Deprenyl. Naunyn Schmiedeberq’s Arch. Pharmacol., 311: 263.Google Scholar
  6. Fowler C. J., 1982, Selective inhibitors of MAO types A and B and their clinical usefulness, Drug future, 7: 501.Google Scholar
  7. Garrick N. A., and Murphy D.L., 1980, Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain. Psychopharmacol., 72: 27.Google Scholar
  8. Glover V., Sandler M., Owen F., and Riley G. J., 1977, Dopamine is a monoamine oxidase B substrate in man, Nature, 265: 80.PubMedCrossRefGoogle Scholar
  9. Johnston J. P., 1968, Some observations upon a new inhibitor of monoamine oxidase in brain tissue, Biochem. Pharmacol., 17: 1285.Google Scholar
  10. Knoll J., and Magyar K., 1972, Some puzzling pharmacological effects of monoamine oxidase inhibitors, Adv. Biochem. Psychopharmacol., 5: 393.Google Scholar
  11. Oreland L., and Gottfries C. -G., 1986, Brain and Brain monoamine oxidase in aging and dementia of Alzheimer’s type, Prog. Neuro-Psychopharmacol. Biol. Psychiat., 10: 533.Google Scholar
  12. Reinikainen K. J., Paljarvi L„ Halonen T., Malminen O., Kosma V. -M., Laakso M., and Riekkinen P. J., 1988, Dopaminergic system and monoamine oxidase-B activity in Alzheimer’s disease, Neurobiol. Aging, 9: 245.PubMedCrossRefGoogle Scholar
  13. Westlund K. N., Denney R. M., Kochersperger L. M., Rose R. M., and Abell C. W., 1985, Distinct monoamine oxidase A and B populations in primate brain, Science, 230: 181.PubMedCrossRefGoogle Scholar
  14. Westlund K. N., Denney R. M., Rose R. M., and Abell C. W., 1988, Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem, Neuroscience, 25: 439.PubMedCrossRefGoogle Scholar
  15. Yates C. M., Allison Y., Simpson J., Maloney A. F. J., and Gordon A., 1979, Dopamine in Alzheimer’s disease and senile dementia, Lancet ii,:851.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shinichi Nakamura
    • 1
  • Osamu Yasuhara
    • 1
  • Toshio Kawamata
    • 1
  • Toru Kimura
    • 1
  • Ichiro Akiguchi
    • 1
  • Jun Kimura
    • 1
  • Masakuni Kameyama
    • 2
  • Noriko Nakamura
    • 3
  • Hiroshi Kimura
    • 4
  1. 1.Department of Neurology, Faculty of MedicineKyoto UniversityKyoto 606Japan
  2. 2.Sumitomo HospitalOsaka 530Japan
  3. 3.Department of Internal MedicineYasui HospitalKyoto 606Japan
  4. 4.Shiga University of Medical ScienceMolecular Neurobiology Research CentreOtsu 520-21Japan

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