Intra-Accumbens Dopaminergic Grafts Restore Methamphetamine-Induced Locomotor Hyperactivity Response and the Release and Metabolism of Dopamine in Rats Having 6-OHDA Lesions in the Ventral Tegmental Area
An impairment of dopaminergic (DAergic) transmission in the mesocorticolimbic system results in deficiencies such as hypoexploration, loss of amphetamine-induced hyperactivity, supersensitive locomotor responses to apomorphine, and other sensorimotor deficiencies. DAergic cell transplantation into the nucleus accumbens (NAC) is reported1,2 to alleviate these deficiencies. In the present study, methamphetamine-induced locomotor activity in an open-field was investigated in order to determine the effects of 6-hydroxydopamine (6-OHDA) lesions in the ventral tegmental area (VTA) and intra-accumbens DAergic grafts. Using an in vivo microdialysis-HPLC (high-performance liquid chromatography) detection system, we aimed to clarify the extent to which a deficiency in locomotor activity and its subsequent recovery are related to dopamine (DA) metabolism in the NAC and the degree to which DA is released. Our present study shows that DAergic grafting restores metabolism and release of DA in the NAC.
KeywordsVentral Tegmental Area DAergic Neuron Methamphetamine Administration DAergic System Microdialysis Method
Unable to display preview. Download preview PDF.