α 1-Antichymotrypsin Influences the Survival of Neurons
Alzheimer’s diseases(AD) is a degenerative disorder characterized by neuronal loss and brain lesions such as senile plaques and neurofibrillary tangles. In the AD brain, abnormal neuronal sprouting responses occur1 . Many proteases and protease inhibitors have been shown to influence the extent of neurite outgrowth from several neuronal cell types in vitro 2,3,4 α 1-Antichymotrypsin (ACT), a serine protease inhibitor, is produced in the liver and its serum levels are elevated in patients with cancer or inflammatory diseases. ACT is associated with senile plaque amyloids5,6. Matsubara reported that its serum level was elevated in AD patients7. The presence of a functional Kunitz protease inhibitor domain in the amyloid protein precursor(APP) molecule carries profound implications for the process of amyloidogenesis in AD8. Thus we studied the effect of protease inhibitors on cultured neurons.
KeywordsHippocampal Neuron Neurite Outgrowth Senile Plaque Serine Protease Inhibitor Hippocampal Cell
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