Long-Term Survival of Grafted Cells, Dopamine Synthesis/Release, Receptor Activity, and Functional Recovery after Grafting of Fetal Nigral Cells in Model Animals of Hemi-Parkinson’s Disease

  • Hitoo Nishino
  • Takeshi Hashitani
  • Kiminao Mizukawa
  • Norio Ogawa
  • Sadao Shiosaka
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Grafting of fetal nigral dopaminergic (DAergic) cells, in DA depleted caudate has been reported to produce the recovery of motor disturbances in animal models of hemi-parkinson’s disease1. In the clinical field, graftings of adrenal medullary tissue into patients with Parkinson’s disease have been performed in about two hundred cases2. However, the results so far are not always satisfactory. It because the basic problems remain to be solved. In the present study, to make clear how long the grafted cells survive, function, and ameliorate motor performance, we grafted nigral DAergic cells in model rats of hemi-parkinson’s disease and investigated the survival of the grafted cells, DA synthesis/release, receptor activity and motor recovery for more than 2 years. Some results have been reported elsewhere3.

Keywords

HPLC Dopamine Tyrosine Trypsin Methamphetamine 

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hitoo Nishino
    • 1
  • Takeshi Hashitani
    • 1
  • Kiminao Mizukawa
    • 2
  • Norio Ogawa
    • 3
  • Sadao Shiosaka
    • 4
  1. 1.Dept. Physiol.Nagoya City Univ. Med. Sch.Nagoya 467Japan
  2. 2.Dept. Anat.Okayama Univ. Med. Sch.Okayama 700Japan
  3. 3.Inst. Neurobiol.Okayama Univ. Med. Sch.Okayama 700Japan
  4. 4.Dept. Neuroanat.Osaka Univ. Med. Sch.Osaka 530Japan

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