Long-Term Survival of Grafted Cells, Dopamine Synthesis/Release, Receptor Activity, and Functional Recovery after Grafting of Fetal Nigral Cells in Model Animals of Hemi-Parkinson’s Disease
Grafting of fetal nigral dopaminergic (DAergic) cells, in DA depleted caudate has been reported to produce the recovery of motor disturbances in animal models of hemi-parkinson’s disease1. In the clinical field, graftings of adrenal medullary tissue into patients with Parkinson’s disease have been performed in about two hundred cases2. However, the results so far are not always satisfactory. It because the basic problems remain to be solved. In the present study, to make clear how long the grafted cells survive, function, and ameliorate motor performance, we grafted nigral DAergic cells in model rats of hemi-parkinson’s disease and investigated the survival of the grafted cells, DA synthesis/release, receptor activity and motor recovery for more than 2 years. Some results have been reported elsewhere3.
KeywordsHPLC Dopamine Tyrosine Trypsin Methamphetamine
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- 3.H. Nishino, T. Hashitani, M. Kumazaki, H. Sato, F. Furuyama, Y. Isobe, N. Watari, M. Kanai and S. Shiosaka, Long-term survival of grafted cells, connection with host neurons, dopamine synthesis/release, and functional recovery after transplantation of fetal nigral cells in rats with unilateral 6-OHDA lesions in the nigrostriatal dopamine pathway, Brain Res. submitted.Google Scholar