Use of MPTP-Hemiparkinsonian (HP) Monkeys to Evaluate Efficacy of Tissue Implants as a Treatment for Parkinson’s Disease

  • I. J. Kopin
  • K. Bankiewicz
  • E. H. Oldfield
  • M. A. Palmatier
  • R. J. Plunkett
  • L. Porrino
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Although severed peripheral neural axons re-establish functional synapses, in the central nervous system damaged axons fail to regenerate. This had been attributed to the lack of production in damaged brain of “neurotrophic substances” to support axonal growth1. During the last 20 years, however, there have been several important discoveries which have made possible serious attempts to promote repair from damage or degeneration in the central nervous system. An increasing number of studies have sought means for retarding degenerative neurological diseases or for replacing degenerated neurons, particularly in Parkinson’s disease.


Caudate Nucleus Human Fetal Tissue Dopaminergic Innervation Tissue Implant Degenerative Neurological Disease 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • I. J. Kopin
    • 1
  • K. Bankiewicz
    • 1
  • E. H. Oldfield
    • 1
  • M. A. Palmatier
    • 1
  • R. J. Plunkett
    • 1
  • L. Porrino
    • 1
  1. 1.National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaUSA

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