Autotransplantation of Parasympathetic Cholinergic Neurons into Alzheimer Model Rat Brain
Senile dementia of the Alzheimer type is a progressive disease in the aged. Based upon the hypothesis relating cholinergic function to Alzheimer’s disease1, the present study was designed to elucidate the effect of transplantation of cholinergic cells on behavioral abnormalities induced in Alzheimer-model rats. With the goal of clinical applicability, autologous vagal ganglion containing many cholinergic cells were used as a donor tissue.
KeywordsSenile Dementia Passive Avoidance Test Cholinergic Function Ibotenic Acid Nodosal Ganglion
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- 2.T.Itakura, M.Nakai, I.Kamei, H.Imaí, Y.Naka, K.Nakai, H.Yokote, T.Okuno, M.Ueno, M.Umemoto, and N.Komai, Transplantation of autonomic ganglia into the brain, Shinkei Kenkyu no Shimpo 32: 808 (1988).Google Scholar