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Autotransplantation of Parasympathetic Cholinergic Neurons into Alzheimer Model Rat Brain

  • Toru Itakura
  • Hideyoshi Yokote
  • Norihiko Komai
  • Mamoru Umemoto
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Senile dementia of the Alzheimer type is a progressive disease in the aged. Based upon the hypothesis relating cholinergic function to Alzheimer’s disease1, the present study was designed to elucidate the effect of transplantation of cholinergic cells on behavioral abnormalities induced in Alzheimer-model rats. With the goal of clinical applicability, autologous vagal ganglion containing many cholinergic cells were used as a donor tissue.

Keywords

Senile Dementia Passive Avoidance Test Cholinergic Function Ibotenic Acid Nodosal Ganglion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P.Davies and A.J.R.Maloney, Selective loss of central cholinergic neurons in Alzheimer’s disease, Lancet 2: 1403 (1976).PubMedCrossRefGoogle Scholar
  2. 2.
    T.Itakura, M.Nakai, I.Kamei, H.Imaí, Y.Naka, K.Nakai, H.Yokote, T.Okuno, M.Ueno, M.Umemoto, and N.Komai, Transplantation of autonomic ganglia into the brain, Shinkei Kenkyu no Shimpo 32: 808 (1988).Google Scholar
  3. 3.
    M.J.Karnovsky,L Roots, A “direct-coloring” thiocholine method for cholin-esterase, J. Histochem. Cytochem. 12: 219 (1964).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Toru Itakura
    • 1
    • 2
  • Hideyoshi Yokote
    • 1
    • 2
  • Norihiko Komai
    • 1
    • 2
  • Mamoru Umemoto
    • 1
    • 2
  1. 1.Dept. of Neurological SurgeryWakayama Medical CollegeWakayama CityJapan
  2. 2.Dept. of PsychologyOsaka City UniversityOsaka CityJapan

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