Advertisement

Modifications in the Levels of Antibodies in the CSF of Parkinson’s Disease Patients Following Adrenal-to-Brain Transplantation

  • Amanda McRae
  • Annelie Wigander
  • Kerstin Lundmark
  • Paul Carvey
  • Annica Dahlström
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

A growing body of evidence suggest that the immune system participates in some neurological disease states such as multiple sclerosis, Alzheimer’s and Parkinson’s disease (PD) (for ref. see McRae-Degueurce et al., 1987, 1988a)

Keywords

Substantia Nigra Neuronal Culture Adrenal Medulla Alzheimer Disease Patient Immunocytochemical Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Carvey, P.M., Kroin, J.S., Zhang, T.J., O’Dorisio, T.M., McRae, A., Dahlström, A., Kao, L.C., Goetz, C.G., Tanner, C.M., Shannon, K.M., and Klawans, H.L., 1988, Biochemical and immunochemical characterization of ventricular CSF from Parkinson’s Disease patients with adrenal medulla transplants, Neurology, 38 (suppl. 1): 144.CrossRefGoogle Scholar
  2. Dahlström, A., Wigander, A., Lundmark, K., Gottfries, C.G., and McRae, A., 1989, Investigations on autoantibodies in Alzheimer’s and Parkinson’s diseases, using defined neuronal cultures. T. Neural Transco. (in press).Google Scholar
  3. McRae-Degueurce, A., Gottfries, C.G., Karlsson, I., Svennerholm, L., and Dahl-ström, A., 1986, Antibodies in the CSF of a Parkinson patient recognizes neurons in rat mesencephalic regions, Acta Physiol. Scand., 126: 313–315.PubMedCrossRefGoogle Scholar
  4. McRae-Degueurce, A., Bööj, S., Haglid, K., Rosengren, L., Karlsson, J.E., Karlsson, I., Wallin, A., Svennerholm, L., Gottfries, C.G., and Dahlström, A., 1987, Antibodies in cerebrospinal fluid of some Alzheimer disease patients recognize cholinergic neurons in the rat central nervous system, Proc. Nat. Acad. Sci., 84: 9214–9218.PubMedCrossRefGoogle Scholar
  5. McRae-Degueurce, A., Rosengren, L.,Haglid, K., Bööj, S.,Gottfries, C.G. Granérus, A.C., and Dahlström A., 1988a, Immunocytochemical investigations on the presence of neuron-specific antibodies in the CSF of Parkinson’s disease cases, Neurochem. Res., 13: 679–684.Google Scholar
  6. McRae-Degueurce, A., Klawans, H.L., Penn, R.D., Dahlström, A., Tanner, C.M., Goetz, C.G., and Carvey, P.M., 1988b, An antibody in the CSF of Parkinson’s disease patients disappears following adrenal medula transplantation, Neurosci. Lett., 94: 192–197.PubMedCrossRefGoogle Scholar
  7. Penn, R.D., Goetz, C.G., Tanner, C.M., Klawans, H.L., Shannon, K.M., Cornelia, C.L., and Witt, T.R., 1988, The adrenal medullary transplant operation for Parkinson’s disease, Neurosurgery, 22: 999–1004.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Amanda McRae
    • 1
    • 2
    • 3
  • Annelie Wigander
    • 1
    • 2
    • 3
  • Kerstin Lundmark
    • 1
    • 2
    • 3
  • Paul Carvey
    • 1
    • 2
    • 3
  • Annica Dahlström
    • 1
    • 2
    • 3
  1. 1.Institute of NeurobiologyUniversity of GöteborgSweden
  2. 2.Rush-Presbyterian St.Luke’s Medical College ChicagoUSA
  3. 3.INSERM-259BordeauxFrance

Personalised recommendations