Carbon Monoxide (CO)-Induced Delayed Amnesia and Delayed Neuronal Death
Recent evidence has indicated that ischemia produces several dysfunctions in the central nervous system. For example, in the passive avoidance task, amnesia is induced 24 hours after ischemia in rats (Yasumatsu et al., 1987; Yamazaki et al., 1984). In addition, “delayed neuronal death” is caused even after the recovery from changes in biochemical and electrophysiological parameters induced by ischemic insult (Kirino, 1982; Pulsinelli et al., 1982).
KeywordsNeuronal Death Pyramidal Cell Passive Avoidance Retention Test Grid Floor
Unable to display preview. Download preview PDF.
- Kinbara, K., Nabeshima, T., Yoshida, S. and Kameyama, T., 1989, Effects of carbon monoxide exposure on the step-down passive avoidance response in mice, Japan. J. Pharmacol., Supp1. 49: 270.Google Scholar
- Nabeshima, T., Yoshida, S., Morinaka, H., Kameyama, T., Thurkauf, A., Rice, K. C., Jacobson, A. E. and Cho, A. K., 1989, MK-801 ameliorates CO-induced delayed amnesia, but potentiates CO-induced acute amnesia, Neurosci. Lett., in press.Google Scholar
- Pulsinelli, W. A., Briely, J. B. and Plum, F., 1982, Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann. Neurol., 11: 491.Google Scholar
- Sidman, R. L., Angevine, J. B., Pierce, E. T., 1971, in: “Atlas of the Mouse Brain and Spinal Cord,” Harvard University Press, Cambridge.Google Scholar