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Some Effects of CNS Cholinergic Neurons on Memory and ACh Release

  • Tsutomu Goto
  • Fumio Kuzuya
  • Hidetoshi Endo
  • Toshihisa Tajima
  • Hiroyuki Ikari
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Summary

The aim of this study is to observe the relationship between the impairment in passive avoidance task induced in rats by the i.p. administration of muscarinic antagonists, scopolamine and methyl-scopolamine, and the changes in acetylcholine (ACh), monoamines output induced by these drugs. Initially we studied the effects of these drugs on the animals’ performance of a step-through passive avoidance task. We then measured the change in ACh and monoamines levels after administration of these drugs using an in vivo brain dialysis technique. Scopolamine was effective in impairing the performance of the passive avoidance task, while methyl-scopolamine did not have clear effects on the performance of the task. With regard to ACh output, scopolamine increased ACh dose-dependently and methyl-scopolamine also affected ACh release. Scopolamine did not affect monoamines release except serotonin.

These data suggest that the accumulation of ACh in the synaptic cleft is involved in the memory deficit induced by scopolamine.

Keywords

Guide Cannula Dark Compartment Muscarinic Antagonist Passive Avoidance Task Retention Trial 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tsutomu Goto
    • 1
  • Fumio Kuzuya
    • 1
  • Hidetoshi Endo
    • 1
  • Toshihisa Tajima
    • 1
  • Hiroyuki Ikari
    • 1
  1. 1.Department of GeriatricsSchool of Medicine Nagoya UniversityShowa-ku, NagoyaJapan

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