Impaired Spatial Learning in Rats with a Trimethyltin-Induced Hippocampal Lesion and the Effect of Fetal Septal Grafting on the Impairment
Trimethyltin (TMT), an organotin compound, is a by-product in the manufacture of dimethyltin chloride, a stabilizing agent for certain plastics. Exposure to TMT causes neuopathological changes in the limbic system of the brain (Brown et al.,1979; Bouldin et al., 1981). An accidental exposure to TMT in humans has been reported to induce a status of mental confusion with generalized epileptic seizures (Fortemps et al., 1987). Among the regions of the central nervous system in rats, the hippocampus subsequently became the focus of research in TMT neuotoxicity. The pyramidal cells of the CA3 and CA4 hippocampal subfields appear to be particularly sensitive to acute toxicity with a single dose of TMT (Dyer et al., 1982). The long-term behavioral sequelae of TMT intoxication have revealed marked hyperactivity and learning impairments (Hagan et al., 1990).
KeywordsSpatial Learning Passive Avoidance Hippocampal Lesion Organotin Compound Pyramidal Cell Layer
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