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Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin

  • Shigeru Takauchi
  • Koho Miyoshi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Recent findings have shown that there is a close relationship between protease inhibitors and amyloid deposits or amyloid precursor protein. Experimentally, an accumulation of neurofilaments in axon terminals, suggesting a connection between protease inhibitor and neurofibrillar pathology, and a prominent accumulation of lipofuscin in neuronal cytoplasma have been induced by the cysteine protease inhibitor leupeptin. These findings indicate that some derangement of protease activity plays a role in the pathological aging process of the CNS.

Keywords

Senile Plaque Amyloid Fibril Axon Terminal Dense Body Neuronal Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shigeru Takauchi
    • 1
  • Koho Miyoshi
    • 1
  1. 1.Department of NeuropsychiatryHyogo College of MedicineNishinomiya 663Japan

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