Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin
Recent findings have shown that there is a close relationship between protease inhibitors and amyloid deposits or amyloid precursor protein. Experimentally, an accumulation of neurofilaments in axon terminals, suggesting a connection between protease inhibitor and neurofibrillar pathology, and a prominent accumulation of lipofuscin in neuronal cytoplasma have been induced by the cysteine protease inhibitor leupeptin. These findings indicate that some derangement of protease activity plays a role in the pathological aging process of the CNS.
KeywordsSenile Plaque Amyloid Fibril Axon Terminal Dense Body Neuronal Process
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