Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin

  • Shigeru Takauchi
  • Koho Miyoshi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Recent findings have shown that there is a close relationship between protease inhibitors and amyloid deposits or amyloid precursor protein. Experimentally, an accumulation of neurofilaments in axon terminals, suggesting a connection between protease inhibitor and neurofibrillar pathology, and a prominent accumulation of lipofuscin in neuronal cytoplasma have been induced by the cysteine protease inhibitor leupeptin. These findings indicate that some derangement of protease activity plays a role in the pathological aging process of the CNS.


Senile Plaque Amyloid Fibril Axon Terminal Dense Body Neuronal Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S. Takauchi and K. Miyoshi, Degeneration of neuronal processes in rats induced by a protease inhibitor, leupeptin, Acta Neuropathol., 78: 380 (1989).PubMedCrossRefGoogle Scholar
  2. 2.
    R.D. Terry, N.K. Gonatas, and M. Weiss, Ultrastructural studies in Alzheimer’s presenile dementia, Am. J. Path., 44: 269 (1964).PubMedGoogle Scholar
  3. 3.
    C.R. Abraham, D.J. Selkoe, and H. Potter, Immunochemical identification of the serine protease inhibitor al-antichymotrypsin in the brain amyloid deposits of Alzheimer’s disease, Cell, 52: 487 (1988).PubMedCrossRefGoogle Scholar
  4. 4.
    N. Kitaguchi, Y. Takahashi, Y. Tokushima, S. Shiojiri, and H. Ito, Novel precursor of Alzheimer’s disease amyloid protein shows protease inhibitory activity, Nature, 331: 530 (1988).PubMedCrossRefGoogle Scholar
  5. 5.
    G.O. Ivy, K. Kitani, and Y. Ihara, Anomalous accumulation of T and ubiquitin immunoreactivities in rat brain caused by protease inhibition and normal aging: a clue to PHF pathogenesis?, Brain Res., 360 (1989).Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shigeru Takauchi
    • 1
  • Koho Miyoshi
    • 1
  1. 1.Department of NeuropsychiatryHyogo College of MedicineNishinomiya 663Japan

Personalised recommendations