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Characteristic of Learning Deficit Induced by Ibotenic Acid Lesion of the Frontal Cortex Related with the Nucleus Basalis of Meynert in Rats

  • Chiaki Hara
  • Nobuya Ogawa
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

The final goal of this study is to develop an animal model of Alzheimer’s disease (AD) for preclinical evaluation of therapeutic drugs. AD has classically been defined as a progressive dementia accompanied by characteristic neuropathological changes such as senile plaques and neurofibrillary tangles, both of which are hallmarks of AD. However, no animals having these neuropathological characteristics exist. On the other hand, the memory dysfunction of AD has been associated with a cortical cholinergic deficiency (DeFeudis, 1988). Therefore, memory dysfunction based on nerve cell loss of the cortex in animals may be adequate as an animal model of AD.

Keywords

Medial Prefrontal Cortex Memory Dysfunction ChAT Activity Ibotenic Acid False Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Chiaki Hara
    • 1
  • Nobuya Ogawa
    • 1
  1. 1.Department of PharmacologyEhime University School of MedicineShigenobu-cho, Onsen-gun, Ehime-kenJapan

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