Effects of Destruction of Nucleus Basalis Meynert on Operant Study and Neurotransmitters in Rats

  • Motoi Shoda
  • Tetsuo Kanno
  • Masahiko Nomura
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


In senile dementia of the Alzheimer type (SDAT), it has already been reported that the activity of neurotransmitters1–3 and number of cells in the nucleus basalis Meynert (nbM)4 are decreased. The purpose of our study was to evaluate changes in and correlation between the activity of neurotransmitters and response of ibotenic acid-lesioned WKY rats (a model of Alzheimer’s disease) in an operant study.


Nucleus Basalis Alzheimer Disease Patient Alzheimer Model Ibotenic Acid Choline Acetyl 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Motoi Shoda
    • 1
  • Tetsuo Kanno
    • 1
  • Masahiko Nomura
    • 2
  1. 1.Department of NeurosurgeryFujita Health University, School of MedicineToyoake, AichiJapan
  2. 2.Department of PhysiologyFujita Health University, School of MedicineToyoake, AichiJapan

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