Effect of the Basal Forebrain Lesions on Memory and Learning Performance in Mice

  • Akane Ishihara
  • Hiroshi Saito
  • Nobuyoshi Nishiyama
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


The loss of cholinergic cells in the basal forebrain (BF), which correlated with the degree of dementia(1), has been found in Alzheimer’s disease patients. The BF cholinergic system has been demonstrated to play an important role in memory function, and many investigation using rats and monkeys indicate that severe deficits in many kinds of learning tasks result from experimental lesioning of this region(2,3).


Basal Forebrain Memory Retention Anterior Cortex ChAT Activity Ibotenic Acid 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Akane Ishihara
    • 1
  • Hiroshi Saito
    • 1
  • Nobuyoshi Nishiyama
    • 1
  1. 1.Department of Chemical Pharmacology Faculty of Pharmaceutical ScienceUniversity of TokyoBunkyo-ku, Tokyo, 113Japan

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