Aging Effects on Schedule-Control Discrimination Learning Test in Aged Rats as a Model of Alzheimer’s Disease
A gradual deterioration of learning ability is one of the common symptoms of advanced age.1 Recent interest has been focused on neural mechanisms and pharmacological treatments of such cognitive deficits in the aged.2 Although appropriate animal models of cognitive aging are necessary to evaluate pharmacological treatment, there is a wide variety of inconsistencies in the literature on learning ability in aged animals. Many factors such as task difficulty, genotype, and early experience are involved in these discrepancies.3 Concerning discrimination learning, diverse findings have also been reported. Several investigators found clear age differences in visual and place discrimination tasks in primates and rodents.3,41n contrast, a number of other reports have shown no age-dependent deficit in similar kinds of discrimination tasks.5,6
KeywordsDiscrimination Task Learning Ability Aged Animal Front Wall Dark Light
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