An Experimental Animal Model for the Study of Cholinergic and Serotonergic Neuronal Activity in Aging Brain

  • Tomoko Yamaguchi
  • Masashi Yamaguchi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Physiological aging of neurons associated with cholinergic as well as serotonergic activities in experimental animals may well be compatible with senile deterioration of selective neuronal activity in demented brain. To date, cumulative information has been reported on decreased synaptic activity of cholinergic neurons in aging rodents, with most studies done with Fischer rats. However, serotonergic involvement, which is persistent in human aging brain, remains unchanged in aging rats as well.


Serotonergic Activity Synaptosomal Membrane Musk Shrew Human Aging Brain Aging Rodent 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tomoko Yamaguchi
    • 1
  • Masashi Yamaguchi
    • 2
  1. 1.Department of BiochemistryTokyo Women’s Medical CollegeShinjuku-ku, Tokyo 162Japan
  2. 2.Minami-Yachimata Mental HospitalChiba-ken 289-11Japan

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