An Experimental Animal Model for the Study of Cholinergic and Serotonergic Neuronal Activity in Aging Brain

  • Tomoko Yamaguchi
  • Masashi Yamaguchi
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)


Physiological aging of neurons associated with cholinergic as well as serotonergic activities in experimental animals may well be compatible with senile deterioration of selective neuronal activity in demented brain. To date, cumulative information has been reported on decreased synaptic activity of cholinergic neurons in aging rodents, with most studies done with Fischer rats. However, serotonergic involvement, which is persistent in human aging brain, remains unchanged in aging rats as well.


Serotonergic Activity Synaptosomal Membrane Musk Shrew Human Aging Brain Aging Rodent 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    T.Yamaguchi and M.Yamaguchi, A new experimental animal for the study of aged-related changes in serotonergic neuronal activity in the brain cortex, Neurochen. Res. 12: 215 (1987)Google Scholar
  2. 2.
    J.Fukuda, T.Aoki, K.Keino and T.Yamaguchi, Age-associated and cell-type specific change in NGFrequirement for neurite regeneration from trigeminal ganglion cells of the shrew (Suncus murinus) in a serum free culture. Develop. Neurosci.,in press(1989)Google Scholar
  3. 3.
    N. Hanai, G.A. Nores, C. NacLeod, C-R. Torresmendes, and S. Hokomori Ganglioside-mediated modulation of cell growth, J. Biol. Chem. 263: 10951 (1988)Google Scholar
  4. 4.
    R. W. Carrell, Enter a proteinase inhibitor, Nature 331: 478 (1988)PubMedCrossRefGoogle Scholar
  5. 5.
    T. Yamaguchi, Usefulness of Suncus as a model of aging brain, Proc. JAAMHD 5: 80 (1987)Google Scholar
  6. 6.
    K-F.J.Chan,Ganglioside-modulated proteiphosphorylation, J. of Biol. Chem. 262: 6248 (1987)Google Scholar
  7. 7.
    C. Peterson and G. E. Gibson, Aging and 3,4,diamonopyridine alter synaptosomal calcium uptake, J. Biol. Chem. 258: 11482 (1983)PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tomoko Yamaguchi
    • 1
  • Masashi Yamaguchi
    • 2
  1. 1.Department of BiochemistryTokyo Women’s Medical CollegeShinjuku-ku, Tokyo 162Japan
  2. 2.Minami-Yachimata Mental HospitalChiba-ken 289-11Japan

Personalised recommendations