Effect of Aging on NADPH-Diaphorase Neurons in Laterodorsal Tegmental Nucleus and Striatum of Senescence Accelerated Mouse (SAM)
Age-related reduction of neuronal number and/or size has been reported in some brain regions of human and experimental animals. Of particular interest are the age-related alterations of cholinergic neurons in the basal forebrain. This cholinergic cell group sends ascending projections into the neocortex, amygdala and hippocampus, and may be associated with memory and cognitive function, both of which are affected in older experimental animals. In fact, neuronal size is reduced in this cholinergic cell group in aged rodents [1, 2]. In addition to the basal forebrain cholinergic neurons, a conspicuous cell group in the pedunculopontine tegmental nucleus (TPP) and laterodorsal tegmental nucleus (TLD) of several species has been described to be cholinergic . This cholinergic cell group in the hindbrain also gives rise to widespread ascending or descending projections to various regions.
KeywordsCholinergic Neuron Basal Forebrain Progressive Supranuclear Palsy Basal Forebrain Cholinergic Neuron Pedunculopontine Tegmental Nucleus
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