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Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain

  • Ichiro Akiguchi
  • Toshio Kawamata
  • Hideo Yagi
  • Haruhiko Akiyama
  • Hiroshi Sugiyama
  • Masaki Ueno
  • Manabu Takemura
  • Mayako Tanaka
  • Mika Irino
  • Toshio Takeda
Part of the Advances in Behavioral Biology book series (ABBI, volume 38A)

Abstract

Senescence Accelerated Mouse (SAM) shows an earlier onset and irreversible advancement of senescence manifested by the following signs and lesions: a loss of activity, skin coarseness, a shortened life span, systemic senile amyloidosis, senile cataract,senile osteoporosis1–3 etc. Further, it was reported that SAM-P/8, a substrain of accelerated senescence prone series with a low incidence of senile amyloidosis, showed the following age-related deterioration in learning ability: SAM-P/8 as well as SAM-P/8/Ta, which is SAM-P/8 bred under specific pathogen-free conditions, exhibited remarkable age-related deterioration in memory and learning in passive avoidance response and hyperactivity in the open field, compared with SAM-R/1 control, a substrain of accelerated senescence resistant series4–5. In searching for the structural basis of such behavioral changes and accelerated senescence, we found age-related pathomorphological changes in the SAM-P/8 brain3. Several changes related to the learning and memory deficits are described herein.

Keywords

Dendritic Spine Reticular Formation Accelerate Senescence Piriform Cortex Hippocampal Pyramidal Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Ichiro Akiguchi
    • 1
  • Toshio Kawamata
    • 1
  • Hideo Yagi
    • 1
  • Haruhiko Akiyama
    • 1
  • Hiroshi Sugiyama
    • 1
  • Masaki Ueno
    • 1
  • Manabu Takemura
    • 1
  • Mayako Tanaka
    • 1
  • Mika Irino
    • 2
  • Toshio Takeda
    • 2
  1. 1.Department of Neurology, Faculty of MedicineKyoto UniversitySakyo-ku, Kyoto 606Japan
  2. 2.Department of Senescence Biology, Chest Disease Research InstituteKyoto UniversitySakyo-ku, Kyoto 606Japan

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