Morphological Changes of the Brain in Senescence Accelerated Mouse (SAM)-P/8, a Newly Developed Memory-Deficient Strain
Senescence Accelerated Mouse (SAM) shows an earlier onset and irreversible advancement of senescence manifested by the following signs and lesions: a loss of activity, skin coarseness, a shortened life span, systemic senile amyloidosis, senile cataract,senile osteoporosis1–3 etc. Further, it was reported that SAM-P/8, a substrain of accelerated senescence prone series with a low incidence of senile amyloidosis, showed the following age-related deterioration in learning ability: SAM-P/8 as well as SAM-P/8/Ta, which is SAM-P/8 bred under specific pathogen-free conditions, exhibited remarkable age-related deterioration in memory and learning in passive avoidance response and hyperactivity in the open field, compared with SAM-R/1 control, a substrain of accelerated senescence resistant series4–5. In searching for the structural basis of such behavioral changes and accelerated senescence, we found age-related pathomorphological changes in the SAM-P/8 brain3. Several changes related to the learning and memory deficits are described herein.
KeywordsDendritic Spine Reticular Formation Accelerate Senescence Piriform Cortex Hippocampal Pyramidal Neuron
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- 3).I. Akiguchi, H. Akiyama, H. Sugiyama, et al, Morphological changes of the brain of senescence accelerated mouse (SAM)-P/8, In: Proceeding of the first SAM Kyoto Symposium; The Council for SAM Research, Kyoto (1987).Google Scholar
- 6).H. Akiyama, M. Kameyama, I. Akiguchi, et al, Periodic acid-Schiff (PAS)-positive, granular structures increase in the brain of senescence accelerated mouse (SAM), Acta Neuropathol. (Berg) 72: 124 (1986).Google Scholar